Closantel Intoxication in a Sheep: Case Study

Rao, Neha; Parmar, J.J.; Sadhu, D.B.; Shah, A.I.; Patel, D.M.

doi:10.20546/ijcmas.2018.710.160

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Closantel toxicity has been previously reported in animals including sheep, cattle, and dogs. 2 Frequent symptoms of toxicity are loss of appetite, ataxia, visual and other neurologic manifestations. 3 There are several reports of ophthalmic side effects in livestock overdosed with Closantel.…”

Section: Discussionmentioning

confidence: 99%

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Closantel retinal toxicity: Recovery from severe vision loss after corticosteroid therapy

Behboudi

Alizadeh

Moghadam

et al. 2022

European Journal of Ophthalmology

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Purpose To present a relatively rare case of retinal toxicity and consequent severe vision loss due to Closantel ingestion. Case report A 37-year-old female presented with sudden painless decrease vision in both eyes. She had no previous history of medical disease and denied any trauma. The patient had accidentally ingested Closantel a few days prior to presentation. Closantel is a veterinary anti-helminthic drug used mainly in livestock. Best corrected visual acuity (BCVA) at presentation was 20/200 bilaterally. There was no relative afferent pupillary defect (RAPD) and red saturation test was normal. Macular optical coherence tomography (OCT) revealed disruption in the outer retinal layer and ellipsoid zone in both eyes. A diagnosis of retinal toxicity due to Closantel was made and the patient was started on 1 mg/kg oral prednisolone acetate. On the 45th day after presentation, her BCVA had improved to 20/20 bilaterally. Conclusion Closantel is a potentially toxic drug causing destruction of the neurosensory retina and visual disturbances. We suggest eye-care personnel awareness regarding the risk of Closantel-induced retinal toxicity and prompt treatment with systemic steroids should be considered.

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Section: Discussionmentioning

confidence: 99%

“…1 It is not used for agriculture, poultry, horses, or household pets. 2 Closantel has no known antidote. Ingestion of Closantel in humans can cause neuro-ophthalmic toxicity.…”

Section: Introductionmentioning

confidence: 99%

Closantel retinal toxicity: Recovery from severe vision loss after corticosteroid therapy

Behboudi

Alizadeh

Moghadam

et al. 2022

European Journal of Ophthalmology

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Residues of an anthelmintic veterinary drug (closantel) detected in red foxes (Vulpes vulpes) in Scotland

Giergiel

Campbell

Giela

et al. 2023

Ecotoxicology and Environmental Safety

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A brief overview of acute poisoning in sheep

Bates¹

2021

Livestock

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Acute poisoning in sheep can occur following ingestion of toxic plants, including plants that they may eat normally such as ivy (Hedera spp.) and plants they avoid unless other forage is unavailable. Poisoning with plants containing grayanotoxins (Pieris and Rhododendron spp.) is very common in sheep, particularly when the weather is poor and they are hungry. Oak (Quercus spp.) poisoning is also relatively common in sheep, particular in years with a heavy acorn crop. Numerous plants contain cardiac glycosides and are a potential risk to sheep. Sudden death is frequently the first signs of plant toxicosis in livestock. Bites from adders (Vipera berus berus) may also occur in sheep but are likely to be underreported as the actual biting event is not witnessed. Envenomation may result in swelling and haematological, renal, hepatic and cardiac effects. Overdosage of drugs with a narrow therapeutic index may also be a risk. One such example is closantel which can result in blindness. Management of acute poisoning in sheep is supportive including removal from exposure, and providing analgesia, rehydration and potentially a rumenotomy for plant exposure in valuable animals.

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Closantel Intoxication in a Sheep: Case Study

Cited by 3 publications

References 4 publications

Closantel retinal toxicity: Recovery from severe vision loss after corticosteroid therapy

Closantel retinal toxicity: Recovery from severe vision loss after corticosteroid therapy

Residues of an anthelmintic veterinary drug (closantel) detected in red foxes (Vulpes vulpes) in Scotland

A brief overview of acute poisoning in sheep

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