Clopidogrel is not associated with increased bleeding complications after full-mouth extraction

Omar, Hesham R.; Socias, Stephanie M.; Powless, R. Andrew; Sprenker, Collin; Karlnoski, Rachel; Mangar, Devanand; Camporesi, Enrico M.

doi:10.1016/j.adaj.2015.01.002

Cited by 13 publications

(4 citation statements)

References 17 publications

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“…Drugs that inhibit platelet function have assumed increased importance in the care of patients with cardiovascular and cerebrovascular diseases, which are leading causes of death worldwide. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

Assessment of postoperative bleeding after dental extractions in patients who are on antiplatelet therapy: A prospective study

Hoda

Navaneetham

Sham

et al. 2021

Ann Maxillofac Surg

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Introduction: Patients with ischemic heart disease are placed on antiplatelet therapy (APT). This study allows a definite protocol to be set which will allow us the make the right judgment when it comes to extractions in patients on APT. Materials and Methods: For this study, 100 patients were taken up for dental extraction after obtaining a thorough case history. Bleeding time was assessed preoperatively for all the patients and patients with normal bleeding time were taken up for surgery under local anesthesia. Local haemostatic measures were employed after the extraction. Patients were monitored for first 30 minutes at the clinic and a telephonic review of all the patients was done at 24 h–48 h interval after the procedure. If there was an active ooze from the surgical site at any point, haemostatic measures with local haemostatic agents were carried out. Results: In patients with mono antiplatelet therapy, bleeding was noted in 16 patients after the 1 h time interval and was absent after 24h–48 h time intervals. The q = 32 and the P < 0.001, making it statistically significant. Regarding patients on dual APT, bleeding was noted in ten patients after 1 h, and in one patient after 24 h with no patients presenting with bleeding at the 48 h time interval. The q = 16.545 and P < 0.001, making it statistically significant. Discussion: The benefits of continuing APT for patients who require dental extraction outweighs the risks of postoperative bleeding. Conclusion: Antiplatelets are used for the prevention of myocardial infarction, ischemic stroke, and vascular death among patients who are at high risk of these events. Antiplatelets have minimal impact on the amount and duration of bleeding following routine dental extractions.

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Section: Discussionmentioning

confidence: 99%

Assessment of postoperative bleeding after dental extractions in patients who are on antiplatelet therapy: A prospective study

Hoda

Navaneetham

Sham

et al. 2021

Ann Maxillofac Surg

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“…Cahill et al [12] advocated the discontinuation of aspirin therapy 5 days before elective surgery. Omar et al [13] conducted a retrospective study on 71 patients receiving clopidogrel who underwent full-mouth extraction. They did not find evidence to recommend that the continuation of clopidogrel during full-mouth extraction was safe.…”

Section: Discussionmentioning

confidence: 99%

Hemostatic Effect of Platelet Rich Fibrin Versus Tranexamic Acid After Tooth Extraction in Patients Under Anticoagulant Therapy

Shams¹

2020

OAJBS

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“…Antiaggregants most commonly applied in both primary and secondary prevention of cardiovascular diseases include acetylsalicylic acid (ASA), clopidogrel, prasugrel, and ticagrelor [7,8]. Acetylsalicylic acid (aspirin) inactivates cyclooxygenase, which inhibits physiological aggregation of blood platelets and development of blood clots by impairing extrinsic pathways of coagulation and clotting for the life spam of the platelet, ranging from 7 to 10 days [5,[9][10][11]. Antiplatelet drugs may be used in the course of single antiplatelet therapy (SAPT), or dual antiplatelet therapy (DAPT).…”

Section: Introductionmentioning

confidence: 99%

Analysing the effectiveness of topical bleeding care following tooth extraction in patients receiving dual antiplatelet therapy-retrospective observational study

et al. 2021

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Background Patients using antiplatelet drugs following infarctions, acute coronary syndrome or stroke pose a significant clinical problem if it is necessary to perform surgery, including dental surgery, since they are at risk of prolonged or secondary post-extraction bleeding. Discontinuation of this therapy is associated with a high risk of serious thromboembolic complications. The purpose of this study was to assess the effectiveness of TachoSil fibrin-collagen patches in stopping and preventing of secondary post-extraction bleeding in patients undergoing chronic antiplatelet therapy. Methods The study was conducted through retrospective examination of the medical records of 153 patients using chronic antiplatelet therapy and those qualified for tooth extraction. The largest group comprised 74 patients using aspirin and clopidogrel as dual platelet antiaggregation therapy; in this group 75 tooth extractions were carried out. In all of the patients TachoSil fibrin-collagen patches and stiches were applied to the wounds resulting from tooth removal. Results Following tooth extraction, primary bleeding was stopped in all the patients and their wounds closed via coagulation within 20–30 min. In eight cases, accounting for 4.9% of the patients, secondary bleeding occurred and was successfully stopped only by applying a pressure dressing soaked in tranexamic acid. Secondary bleeding occurred in three patients on the second day and in five patients on the third day following tooth removal. Conclusion Topical application of TachoSil patches following tooth removal in patients using single or dual antiplatelet therapy effectively stopped bleeding and prevented secondary bleeding after tooth extraction.

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Clopidogrel is not associated with increased bleeding complications after full-mouth extraction

Cited by 13 publications

References 17 publications

Assessment of postoperative bleeding after dental extractions in patients who are on antiplatelet therapy: A prospective study

Assessment of postoperative bleeding after dental extractions in patients who are on antiplatelet therapy: A prospective study

Hemostatic Effect of Platelet Rich Fibrin Versus Tranexamic Acid After Tooth Extraction in Patients Under Anticoagulant Therapy

Analysing the effectiveness of topical bleeding care following tooth extraction in patients receiving dual antiplatelet therapy-retrospective observational study

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