Clopidogrel but not Aspirin prevents acute smoking-induced platelet aggregation in patients with stable coronary artery disease

Addad, Faouzi; Chakroune, Tahar; Asma, Ayed; Abderazek, Fatma; Dridi, Zohra; Ghrissi, I.; Hassine, Mohsen; Gamra, Habib; Elalamy, Ismaı̈l

doi:10.1016/j.thromres.2008.05.001

Cited by 10 publications

(4 citation statements)

References 16 publications

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“…In ex vivo analysis, clopidogrel, but not aspirin, attenuated platelet aggregation in smokers(28). Other studies indicate that aspirin alone is not sufficient to block the effects of smoking on platelet function.…”

Section: Discussionmentioning

confidence: 99%

Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism

Dong

Caicedo

Han

et al. 2010

Thrombosis Research

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Section: Discussionmentioning

confidence: 99%

Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism

Dong

Caicedo

Han

et al. 2010

Thrombosis Research

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“…In addition to the type of test, multiple technical and clinical factors can also confound the results of platelet function tests. These include posture [14], quality of the blood draw [15], platelet response to endothelial injury that occurs during blood collection[16], time of day [9,17], sample transport conditions [15], platelet count [15], hemolysis [15], exercise [18], smoking [19,20], age [21], gender [22], presence of infection [23], obesity [24,25], glucose control in diabetics [25,26], hemoglobin [27], serum cholesterol [26] and triglyceride [28], as well as use of concomitant agents, such as anticoagulants [29]. …”

Section: Prevalence Of Laboratory Antiplatelet Resistancementioning

confidence: 99%

Antiplatelet resistance in stroke

Topçuoğlu

Arsava

Ay³

2011

Expert Review of Neurotherapeutics

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Although the exact prevalence of antiplatelet resistance in ischemic stroke is not known, estimates about the two most widely used antiplatelet agents – aspirin and clopidogrel – suggest that the resistance rate is high, irrespective of the definition used and parameters measured. Inadequate antiplatelet responsiveness correlates with an increased risk of recurrent ischemic vascular events in patients with stroke and acute coronary syndrome. It is not currently known whether tailoring antiplatelet therapy based on platelet function test results translates into a more effective strategy to prevent secondary vascular events after stroke. Large-scale clinical trials using a universally accepted definition and standardized measurement techniques for antiplatelet resistance are needed to demonstrate whether a ‘platelet-function test-guided antiplatelet treatment’ strategy translates into improved stroke care. This article gives an overview of the clinical importance of laboratory antiplatelet resistance, describes the challenges for platelet-function test-guided antiplatelet treatment and discusses practical issues about the management of patients with aspirin and/or clopidogrel resistance.

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“…e greater risk for coronary heart disease in women than men is possibly attributed to higher absorption of toxic chemicals in women as well [19]. Smoking induces platelet hyperactivity reducing the responsiveness of antiplatelet drugs like aspirin in patients with stable CAD [20]. A prospective cohort study stated that epigenetic alterations like the degree of methylation in a gene locus was associated with mortality in a population of stable CAD [21].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Smoking on Clinical Outcomes after Percutaneous Coronary Intervention in Women Compared to Men

Mohammadi

Zibaeenezhad

Sayadi

et al. 2021

Journal of Interventional Cardiology

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Background. For decades, cardiovascular diseases (CVD) have been known as men’s disease. However, recent research studies showed that they have become more common in women. Smoking is a strong risk factor for CVD especially that of coronary artery disease (CAD). Several studies reported that women are more susceptible to drastic sequels of smoking than men. There is limited data regarding the impact of smoking on post-revascularization clinical events stratified by gender. This study aimed to investigate if gender significantly changes the incidence of adverse clinical outcomes after percutaneous coronary intervention (PCI) among those with history of smoking. Methods. Participants were selected from two hospitals from 2003 to 2019. Among patients who had PCI (index PCI), those with stable CAD who underwent elective PCI were included. Exclusion criteria were defined as primary PCI and those with multiple prior revascularizations. Participants were followed up seeking for major adverse cardiac events (MACE) including revascularization (PCI or coronary artery bypass grafting), myocardial infarction, and coronary death in three time intervals according to the time of index PCI (short term: up to 24 hours, mid-term: 24 hours to less than 6 months, and long term: more than 6 months). Results. Of the 1799 patients, 61% were men and 47.08% had history of smoking (75% of the smokers were men). At the time of index PCI, smokers were significantly younger than nonsmokers. Also, MACE were significantly higher in smokers than nonsmokers, which was particularly pronounced at the long-term interval. In the nonsmokers group, there was no difference in MACE occurrence between men and women. However, of the smokers, women showed significantly higher MACE rate compared with men peers. Conclusion. Smoking makes women more prone to MACE in comparison to men among patients with stable CAD after PCI with drug-eluting stent.

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Clopidogrel but not Aspirin prevents acute smoking-induced platelet aggregation in patients with stable coronary artery disease

Cited by 10 publications

References 16 publications

Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism

Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism

Antiplatelet resistance in stroke

The Impact of Smoking on Clinical Outcomes after Percutaneous Coronary Intervention in Women Compared to Men

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