Clopidogrel and modified-release dipyridamole for the prevention of occlusive vascular events (review of Technology Appraisal No. 90): a systematic review and economic analysis

Abstract

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The prognostic utility of tests of platelet function for the detection of ‘aspirin resistance’ in patients with established cardiovascular or cerebrovascular disease: a systematic review and economic evaluation

“…Where a major bleed occurred, a one-off reduction in utility was applied. The utility values were obtained from previous studies, [276][277][278] and entered into the model as beta distributions (see Table 78). …”

“…274 The source of fatal stroke and MI costs was an economic modelling study concerning other antiplatelet therapy for cardiovascular disease. 276 The exact split between stroke and MI events is not known, therefore an estimate of 20% stroke and 80% MI was used, and costs weighted accordingly. The cost of a major bleed assumed that 75% of bleeds were GI and 25% were ICH.…”

Prasugrel (Efient®) with percutaneous coronary intervention for treating acute coronary syndromes (review of TA182): systematic review and economic analysis

“…stroke) when compared with the general population. 6 There are three main types of ACS diagnosed by clinical history, electrocardiography (ECG) and levels of cardiac enzymes: (1) ST segment elevation myocardial infarction (STEMI), (2) non-ST segment elevation myocardial infarction (NSTEMI) and (3) unstable angina (UA). A diagnosis of STEMI indicates that the affected artery is completely occluded, resulting in progressive necrosis of the area of heart muscle dependent on its blood supply.…”

Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials

“…These annual costs were taken from Greenhalgh et al 119 and inflated to 2013/14 prices. Separate costs were provided for disabling and non-disabling stroke; according to Davies et al, 15 58% of strokes are disabling and this percentage was used to weight the two continuing care costs for stroke.…”