Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor

Park, Linda; Martin, Unja; Garka, Kirsten E.; Gliniak, Brian; Santo, James P. Di; Müller, Werner; Largaespada, David A.; Copeland, Neal G.; Jenkins, Nancy A.; Farr, Andrew G.; Ziegler, Steven F.; Morrissey, Philip J.; Paxton, Raymond J.; Sims, John E.

doi:10.1084/jem.192.5.659

Cited by 367 publications

(150 citation statements)

References 39 publications

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“…Thus, precursors from ␥c-deficient mice do not respond to IL-7 but respond to TSLP, whereas precursors isolated from IL-7R␣-deficient mice respond to neither IL-7 nor TSLP (31).…”

Section: Tslp Can Drive the Generation Of B1 Cells From Fl Precursorsmentioning

confidence: 94%

“…Discussion TSLP was initially described as a cytokine able to drive B lymphocyte differentiation (17). In the past 3 years a renewed interest in the biological activities of this cytokine occurred, after the publication of its sequence (37), the characterization of its receptor complex (30,31), and the description of its activity on human dendritic cells (38,39). We reported recently that TSLP is able to support B lymphocyte production from FL, but not adult BM, pro-B cells (19) and showed that TSLP is responsible for the vast majority of the B lymphocytes that are generated in the absence of IL-7 signaling (19,21,32).…”

Section: Tslp Supports the Proliferation Of Adult Large Pre-b But Nomentioning

confidence: 99%

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Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment

Vosshenrich

Cumano

Müller

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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IL-7 and thymic stromal lymphopoietin (TSLP) are two major cytokines controlling murine B cell development. IL-7 has been studied extensively, but only recently has it become possible to unravel the role of TSLP in detail. We studied the biological activities of TSLP in B cell development at distinct ages in the mouse. On the one hand, TSLP is able to give rise to a measurable B1 cell compartment derived from fetal liver pro-B cells, although, as is the case for B2 cells, it does not play a prevalent role in the development of this subset. On the other hand, TSLP drives the proliferation of pro-B cells from the fetal and neonatal liver, but in the bone marrow environment, B cell precursors require pre-B cell receptor expression for TSLP responsiveness.

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“…Thus, precursors from ␥c-deficient mice do not respond to IL-7 but respond to TSLP, whereas precursors isolated from IL-7R␣-deficient mice respond to neither IL-7 nor TSLP (31).…”

Section: Tslp Can Drive the Generation Of B1 Cells From Fl Precursorsmentioning

confidence: 94%

Section: Tslp Supports the Proliferation Of Adult Large Pre-b But Nomentioning

confidence: 99%

Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment

Vosshenrich

Cumano

Müller

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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“…A third group identified it as an expressed sequence tag (EST) that had substantial homology to the erythropoietin receptor cytoplasmic domain, but then it was directly demonstrated that this orphan receptor was in fact the elusive TSLPR (59). Another group reported the cloning of TSLP as well as its receptor (60,63). TSLP only weakly binds to TSLPR but exhibits higher affinity to the combination of TSLPR and IL-7R␣.…”

Section: Il-7 and Tslp And The Sharing Of Il-7ramentioning

confidence: 99%

“…Interestingly, the receptor for TSLP contains its own distinctive receptor chain, TSLPR, as well as IL-7R␣ (59,60). Thus, TSLP and IL-7 share IL-7R␣ as a common receptor component (Fig.…”

Section: Il-7 and Tslp And The Sharing Of Il-7ramentioning

confidence: 99%

Cytokine and Cytokine Receptor Pleiotropy and Redundancy

Ozaki

Leonard

2002

Journal of Biological Chemistry

293

200

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“…The TSLP receptor complex is a heterodimer that consists of a low-affinity ligand binding chain, the TSLP receptor (TSLPR), and the IL-7 receptor ␣ chain (IL-7R␣) (5,6). TSLP and TSLPR have also been identified and characterized in humans, and the human TSLP receptor complex has been shown to also be a heterodimer that is composed of the TSLPR and IL-7R␣ chains (7,8).…”

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confidence: 99%

Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFκB

Lee¹,

Ziegler

2007

Proc. Natl. Acad. Sci. U.S.A.

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315

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The epithelial-derived cytokine thymic stromal lymphopoietin (TSLP) is important for the initiation of allergic airway inflammation through a dendritic cell-mediated T helper 2 response. To identify the factors that control TSLP expression, we examined the ability of inflammatory mediators to regulate TSLP production in human airway epithelial cells. We found that both IL-1␤ and TNF-␣ were capable of inducing rapid TSLP production in primary human bronchial airway epithelial cells. We further characterized the human TSLP gene promoter, using two human epithelial cell lines, 16HBEo ؊ and A549, and showed that IL-1␤-and TNF-␣-mediated human TSLP promoter activation in these cells was mediated by an upstream NF B site. Mutation of this NF B site abolished activation, as did overexpression of a dominant-negative version of I B kinase (IKK)␤ (a kinase acting on I B, the inhibitor of NF B). Interestingly, human TSLP mRNA levels were also increased after exposure to Toll-like receptor (TLR) 2, TLR8, and TLR9 ligands, further supporting an important role for NF B in TSLP gene regulation. Similarly, analysis of the mouse TSLP gene promoter revealed the presence of a similarly situated NF B site that was also critical for IL-1␤-inducible expression of mouse TSLP. Taken together, these results demonstrate that the inflammatory mediators IL-1␤ and TNF-␣ regulate human TSLP gene expression in an NF B-dependent manner.proinflammatory cytokine ͉ T helper 2 inflammation ͉ transcriptional regulation T hymic stromal lymphopoietin (TSLP) is a cytokine that was originally identified in culture supernatants of a mouse thymic stromal cell line and has been shown to support the development of pre-B cells to B220 ϩ IgM ϩ immature B cells (1-4). The TSLP receptor complex is a heterodimer that consists of a low-affinity ligand binding chain, the TSLP receptor (TSLPR), and the IL-7 receptor ␣ chain (IL-7R␣) (5, 6). TSLP and TSLPR have also been identified and characterized in humans, and the human TSLP receptor complex has been shown to also be a heterodimer that is composed of the TSLPR and IL-7R␣ chains (7,8). Although the degree of sequence homology between human and mouse TSLP and between human and mouse TSLPR is quite low (43% and 39%, respectively), the expression profiles are similar in the two species, with B cells and CD11c ϩ dendritic cells being the primary cell populations expressing the TSLPR (ref. 9 and S.F.Z. and D. R. J. Rawlings, unpublished results). TSLP is produced primarily by epithelial cells in the lungs, gut, and skin (8). Recent work (e.g., refs. 10 and 11) has shown that TSLP levels are increased at sites of inflammation. For example, lesional skin from patients with atopic dermatitis displayed markedly elevated TSLP expression, whereas uninvolved skin did not (10). Similarly, airway epithelium from asthmatics showed increased TSLP mRNA expression (11) and supported a role for TSLP in promoting T helper 2-type allergic inflammation. CD4 ϩ T cells, primed by TSLP-treated dendritic cells, produce the proallergic cy...

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Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor

Cited by 367 publications

References 39 publications

Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment

Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment

Cytokine and Cytokine Receptor Pleiotropy and Redundancy

Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFκB

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