Cloning of the mRNA of overexpression in colon carcinoma-1

Pibouin, Laurence; Villaudy, J.; Ferbus, Didier; Muleris, Martine; Prospéri, Marie-Thérèse; Remvikos, Y; Goubin, Gérard

doi:10.1016/s0165-4608(01)00634-3

Cited by 95 publications

(36 citation statements)

References 9 publications

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“…The AGD3 transcript is the only TMD that was previously investigated: it was reported to be an ncRNA that is overexpressed in cancer tissues (overexpressed in colon carcinoma-1; OCC-1 ), although its molecular function is still unknown (32). To assess the functions of the AGD3 transcript, we investigated the degree of sequence conservation across the entire AGD3 locus.…”

Section: Resultsmentioning

confidence: 99%

Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation

Kikuchi

Fukuda

Ito

et al. 2009

Nucleic Acids Research

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Mammalian transcriptome analysis has uncovered tens of thousands of novel transcripts of unknown function (TUFs). Classical and recent examples suggest that the majority of TUFs may underlie vital intracellular functions as non-coding RNAs because of their low coding potentials. However, only a portion of TUFs have been studied to date, and the functional significance of TUFs remains mostly uncharacterized. To increase the repertoire of functional TUFs, we screened for TUFs whose expression is controlled during differentiation of pluripotent human mesenchymal stem cells (hMSCs). The resulting six TUFs, named transcripts related to hMSC differentiation (TMDs), displayed distinct transcriptional kinetics during hMSC adipogenesis and/or osteogenesis. Structural and comparative genomic characterization suggested a wide variety of biologically active structures of these TMDs, including a long nuclear non-coding RNA, a microRNA host gene and a novel small protein gene. Moreover, the transcriptional response to established pathway activators indicated that most of these TMDs were transcriptionally regulated by each of the two key pathways for hMSC differentiation: the Wnt and protein kinase A (PKA) signaling pathways. The present study suggests that not only TMDs but also other human TUFs may in general participate in vital cellular functions with different molecular mechanisms.

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Section: Resultsmentioning

confidence: 99%

Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation

Kikuchi

Fukuda

Ito

et al. 2009

Nucleic Acids Research

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“…This gene also belongs to the lncRNA family involved in cellular differentiation and proliferation as post-transcriptional regulators of splicing or as molecular decoys for miRNA [28], [29]. The expression of lncRNAs is deregulated in many different cancers, including colon cancer [30], and some studies suggest a role in cancer initiation, progression and metastasis [31]. The association reported in previous GWAS between CRC susceptibility and SNPs located at 8q24 could be due to the PRNCR1 locus, a lncRNA member [32].…”

Section: Discussionmentioning

confidence: 99%

A Colorectal Cancer Susceptibility New Variant at 4q26 in the Spanish Population Identified by Genome-Wide Association Analysis

Real

Ruiz

Gayán³

et al. 2014

PLoS ONE

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BackgroundNon-hereditary colorectal cancer (CRC) is a complex disorder resulting from the combination of genetic and non-genetic factors. Genome–wide association studies (GWAS) are useful for identifying such genetic susceptibility factors. However, the single loci so far associated with CRC only represent a fraction of the genetic risk for CRC development in the general population. Therefore, many other genetic risk variants alone and in combination must still remain to be discovered. The aim of this work was to search for genetic risk factors for CRC, by performing single-locus and two-locus GWAS in the Spanish population.ResultsA total of 801 controls and 500 CRC cases were included in the discovery GWAS dataset. 77 single nucleotide polymorphisms (SNP)s from single-locus and 243 SNPs from two-locus association analyses were selected for replication in 423 additional CRC cases and 1382 controls. In the meta-analysis, one SNP, rs3987 at 4q26, reached GWAS significant p-value (p = 4.02×10−8), and one SNP pair, rs1100508 CG and rs8111948 AA, showed a trend for two-locus association (p = 4.35×10−11). Additionally, our GWAS confirmed the previously reported association with CRC of five SNPs located at 3q36.2 (rs10936599), 8q24 (rs10505477), 8q24.21(rs6983267), 11q13.4 (rs3824999) and 14q22.2 (rs4444235).ConclusionsOur GWAS for CRC patients from Spain confirmed some previously reported associations for CRC and yielded a novel candidate risk SNP, located at 4q26. Epistasis analyses also yielded several novel candidate susceptibility pairs that need to be validated in independent analyses.

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“…Recent studies have revealed the contribution of ncRNAs as proto-oncogene [31], tumor suppressor gene [32], drivers of metastasis transformation in cancer development [33]. The expression of lncRNAs is deregulated in different cancers, including colon cancer [34]. Several lines of evidence have shown that SNPs in lncRNAs may influence the process of splicing and stability of mRNA conformation, resulting in the modification of its interacting partners [19,35].…”

Section: Introductionmentioning

confidence: 99%

Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer

Sun

Liang

et al. 2013

J Exp Clin Cancer Res

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BackgroundGenome-wide association studies have identified that genetic variants in 8q24 confer susceptibility to colorectal cancer (CRC). Recently, a novel lncRNA (PRNCR1) that located in the 8q24 was discovered. Single nucleotide polymorphisms (SNPs) in the lncRNAs may influence the process of splicing and stability of mRNA conformation, resulting in the modification of its interacting partners. We hypothesized that SNPs in the lncRNA PRNCR1 may be related to the risk of CRC.MethodsWe conducted a case–control study and genotyped five tag SNPs in the lncRNA PRNCR1 in 908 subjects including 313 cases with CRC and 595 control subjects using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) assay.ResultsIn overall analyses, we found that the rs13252298 and rs1456315 were associated with significantly decreased risks of CRC. In stratification analyses, we found that CRC patients carrying the rs1456315G were likely to have a tumor size of greater than 5 cm (G vs. A: adjusted OR = 1.56, 95% CI: 1.10-2.23). Additionally, patients with the rs7007694C and rs16901946G had decreased risks to develop poorly differentiated CRC, whereas patients with the rs1456315G had an increased risk to develop poorly differentiated CRC.ConclusionThese findings suggest that SNPs in the lncRNA PRNCR1 may contribute to susceptibility to CRC.

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Cloning of the mRNA of overexpression in colon carcinoma-1

Cited by 95 publications

References 9 publications

Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation

Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation

A Colorectal Cancer Susceptibility New Variant at 4q26 in the Spanish Population Identified by Genome-Wide Association Analysis

Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer

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