Cloning of local growth factors involved in the determination of muscle mass

Goldspink, Geoffrey

doi:10.1136/bjsm.34.3.159

Cited by 10 publications

(5 citation statements)

References 13 publications

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“…In contrast, the introduction of rAAVIGF-IB did not affect muscle mass at all in mature animals, even though there was more total IGF-I present. In addition, unlike plasmid delivery of IGF-IB (MGF) to young animals in which hypertrophy was observed 2 wk postinjection (16), viral delivery of IGF-IB did not promote hypertrophy until 2 mo after injection. Again, these differences might be explained by the presence of an activated satellite cell population subjected to IGF-IB.…”

Section: Discussionmentioning

confidence: 99%

Viral expression of insulin-like growth factor-I isoforms promotes different responses in skeletal muscle

Barton¹

2006

Journal of Applied Physiology

103

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Insulin-like growth factor I (IGF-I) is a critical protein for skeletal muscle development and regeneration. Its ability to promote skeletal muscle hypertrophy has been demonstrated by several methods. Alternative splicing of the Igf-1 gene does not affect the mature IGF-I protein but does produce different E peptide extensions, which have been reported to modify the potency of IGF-I. Viral-mediated delivery of murine IGF-IA and IGF-IB into skeletal muscle of 2-wk-old and 6-mo-old mice was utilized to compare the effects of the isoforms on muscle mass. In young mice, tissue content of IGF-I protein was significantly higher in rAAV-treated muscles than control muscles at 1, 2, and 4 mo postinjection. Viral injection of IGF-IB produced two- to sevenfold more IGF-I than rAAVIGF-IA. Hypertrophy was observed 2 and 4 mo postinjection, where both rAAVIGF-IA and rAAVIGF-IB were equally effective in increasing muscle mass. These results suggest that there is a threshold of IGF-I production necessary to promote muscle hypertrophy in young growing animals regardless of isoform. In 6-mo-old animals, only rAAVIGF-IA produced significant increases in muscle size, even though increased IGF-I content was observed after injection of both isoforms. Therefore, the ability for IGF-IB to promote muscle hypertrophy is only effective in growing animals, suggesting that the bioavailability of this isoform or its receptor affinity diminishes with age.

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Section: Discussionmentioning

confidence: 99%

Viral expression of insulin-like growth factor-I isoforms promotes different responses in skeletal muscle

Barton¹

2006

Journal of Applied Physiology

103

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“…MGF appears to be designed for local action and has not been demonstrated to enter the blood stream in any quantity [44,64]. MGF has no known systemic interaction and has its own action model that is independent from other IGF-I splice variants.…”

Section: Mechanisms Of Mgf Actionmentioning

confidence: 99%

IGF-IEc expression, regulation and biological function in different tissues

Dai

Yeung

et al. 2010

Growth Hormone & IGF Research

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“…As is the case of androgens, the administration of GH or its secretagogues (substances that induce release of endogenous GH from the pituitary gland) is able to increase muscle mass but without clear functional benefits (5,199,200). Finally, there are promising results with the administration of IGF-1, the mechano growth factor (MGF) and other growth factors in various chronic conditions that affect muscle mass (201)(202)(203), but there is still a lack of large studies in COPD patients.…”

Section: Correction Of Nutritional Abnormalitiesmentioning

confidence: 99%

Clinical management of chronic obstructive pulmonary disease patients with muscle dysfunction

et al. 2016

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Muscle dysfunction is frequently observed in chronic obstructive pulmonary disease (COPD) patients, contributing to their exercise limitation and a worsening prognosis. The main factor leading to limb muscle dysfunction is deconditioning, whereas respiratory muscle dysfunction is mostly the result of pulmonary hyperinflation. However, both limb and respiratory muscles are also influenced by other negative factors, including smoking, systemic inflammation, nutritional abnormalities, exacerbations and some drugs. Limb muscle weakness is generally diagnosed through voluntary isometric maneuvers such as handgrip or quadriceps muscle contraction (dynamometry); while respiratory muscle loss of strength is usually recognized through a decrease in maximal static pressures measured at the mouth. Both types of measurements have validated reference values. Respiratory muscle strength can also be evaluated determining esophageal, gastric and transdiaphragmatic maximal pressures although there is a lack of widely accepted reference equations. Non-volitional maneuvers, obtained through electrical or magnetic stimulation, can be employed in patients unable to cooperate. Muscle endurance can also be assessed, generally using repeated submaximal maneuvers until exhaustion, but no validated reference values are available yet. The treatment of muscle dysfunction is multidimensional and includes improvement in lifestyle habits (smoking abstinence, healthy diet and a good level of physical activity, preferably outside), nutritional measures (diet supplements and occasionally, anabolic drugs), and different modalities of general and muscle training.

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Cloning of local growth factors involved in the determination of muscle mass

Cited by 10 publications

References 13 publications

Viral expression of insulin-like growth factor-I isoforms promotes different responses in skeletal muscle

Viral expression of insulin-like growth factor-I isoforms promotes different responses in skeletal muscle

IGF-IEc expression, regulation and biological function in different tissues

Clinical management of chronic obstructive pulmonary disease patients with muscle dysfunction

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