Cloning of chicken 11β-hydroxysteroid dehydrogenase type 1 and its tissue distribution

Klusoňová, Petra; Kučka, Marek; Ergang, Peter; Mikšı́k, Ivan; Bryndová, Jana; Pácha, Jiřı́

doi:10.1016/j.jsbmb.2008.06.004

Cited by 12 publications

(4 citation statements)

References 29 publications

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“…To our knowledge, no studies have examined seasonal 310 variation in 11β-HSD in any avian species, although both isoforms of 11β-HSD are thought to be conserved across most vertebrates (Chapman et al, 2013), and studies of enzymatic activity and 312 gene expression have reported what appears to be one or both of the 11β-HSD isoforms in birds 313 (Katz et al, 2010;Kucka et al, 2006). Genes for these enzymes have also been cloned in 314 chickens (Klusonova et al, 2008). 315…”

Section: Prediction 4: Pre-breeding Birds Alter Enzyme Activity To Inmentioning

confidence: 99%

Does corticosterone regulate the onset of breeding in free-living birds?: The CORT-Flexibility Hypothesis and six potential mechanisms for priming corticosteroid function

Lattin

Breuner

Romero

2016

Hormones and Behavior

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For many avian species, the decision to initiate breeding is based on information from a variety of environmental cues, including photoperiod, temperature, food availability, and social interactions. There is evidence that the hormone corticosterone may be involved in delaying the onset of breeding in cases where supplemental cues, such as low food availability and inclement weather, indicate that the environment is not suitable. However, not all studies have found the expected relationships between breeding delays and corticosterone titers. In this review, we present the hypothesis that corticosterone physiology mediates flexibility in breeding initiation (the "CORT-Flexibility Hypothesis"), and propose six possible corticosterone-driven mechanisms in pre-breeding birds that may delay breeding initiation: altering hormone titers, negative feedback regulation, plasma binding globulin concentrations, intracellular receptor concentrations, enzyme activity and interacting hormone systems. Based on the length of the breeding season and species-specific natural history, we also predict variation in corticosterone-regulated pre-breeding flexibility. Although few studies thus far have examined mechanisms beyond plasma hormone titers, the CORT-Flexibility Hypothesis is grounded on a solid foundation of research showing seasonal variation in the physiological stress response and knowledge of physiological mechanisms modulating corticosteroid effects. We propose six possible mechanisms as testable and falsifiable predictions to help clarify the extent of HPA axis regulation of the initiation of breeding.

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Section: Prediction 4: Pre-breeding Birds Alter Enzyme Activity To Inmentioning

confidence: 99%

Does corticosterone regulate the onset of breeding in free-living birds?: The CORT-Flexibility Hypothesis and six potential mechanisms for priming corticosteroid function

Lattin

Breuner

Romero

2016

Hormones and Behavior

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“…Refeeding lowered CORT concentrations to control levels, suggesting the rapid (Յ15 minutes) metabolism or clearance of CORT once food becomes available. Many tissues express 11␤-hydroxysteroid dehydrogenase type 2 (11␤-HSD2) which inactivates CORT to dehydrocorticosterone (51,52). Earlier studies have reported a half-life for CORT in plasma of 10 -25 minutes under baseline conditions (53,54), but more recent studies suggest shorter times of 5-10 minutes in rats (55)(56)(57).…”

Section: An Acute Fast Has Dramatic Effects On Body Mass Muscle and Adrenal Steroidsmentioning

confidence: 99%

Fasting Increases Aggression and Differentially Modulates Local And Systemic Steroid Levels in Male Zebra Finches

2013

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Aggression enables individuals to obtain and retain limited resources. Studies of the neuroendocrine regulation of aggression have focused on territorial and reproductive contexts. By contrast, little is understood concerning the neuroendocrine regulation of aggression over other resources, such as food. Here, we developed a paradigm to examine the role of steroids in food-related aggression. In groups of male zebra finches, a 6-hour fast decreased body mass and increased aggressive interactions among subjects that competed for a point source feeder. Fasting also dramatically altered circulating steroid levels by decreasing plasma testosterone but not estradiol (E2). By contrast, both plasma corticosterone and dehydroepiandrosterone (DHEA) concentrations were elevated with fasting. Interestingly, short-term access to food (15 minutes) after fasting normalized circulating steroid levels. Fasting increased corticosterone levels in a wide range of peripheral tissues but increased DHEA levels specifically in adrenal glands and liver; these effects were quickly normalized with refeeding. DHEA can be metabolized within specific brain regions to testosterone and E2, which promote the expression of aggression. We measured E2 in microdissected brain regions and found that fasting specifically increased local E2 levels in 3 regions: the periaqueductal gray, ventral tegmental area, and ventromedial nucleus of the hypothalamus. These regions are part of the vertebrate social behavior network and regulate the expression of aggression. Together, these data suggest that fasting stimulates secretion of DHEA from the adrenals and liver and subsequent conversion of DHEA to E2 within specific brain regions, to enable individuals to compete for limited food resources.

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“…Like 11ß HSD2, 11ß HSD1 has received little if any experimental attention in studies of songbird stress physiology. The only studies in birds that have assessed this enzyme utilize chicken as a model system, and suggest that 11ß HSD1 is expressed in brain at lower levels than the kidney, intestine, and liver (Klusoňová et al, 2008). We recently designed PCR primers for 11ß HSD1 based on the predicted zebra finch sequence and have identified expression in a mix of kidney and liver, as well as in the HP.…”

Section: Mechanisms Of Cort Regulationmentioning

confidence: 99%

Determinants and significance of corticosterone regulation in the songbird brain

Rensel

Schlinger

2016

General and Comparative Endocrinology

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Songbirds exhibit significant adult neuroplasticity that, together with other neural specializations, makes them an important model system for neurobiological studies. A large body of work also points to the songbird brain as a significant target of steroid hormones, including corticosterone (CORT), the primary avian glucocorticoid. Whereas CORT positively signals the brain for many functions, excess CORT may interfere with natural neuroplasticity. Consequently, mechanisms may exist to locally regulate CORT levels in brain to ensure optimal concentrations. However, most studies in songbirds measure plasma CORT as a proxy for levels at target tissues. In this paper, we review literature concerning circulating CORT and its effects on behavior in songbirds, and discuss recent work suggesting that brain CORT levels are regulated independently of changes in adrenal secretion. We review possible mechanisms for CORT regulation in the avian brain, including corticosteroid-binding globulins, p-glycoprotein activity in the blood-brain-barrier, and CORT metabolism by the 11β hydroxysteroid dehydrogenases. Data supporting a role for CORT regulation within the songbird brain have only recently begun to emerge, suggesting that this is an avenue for important future research.

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Cloning of chicken 11β-hydroxysteroid dehydrogenase type 1 and its tissue distribution

Cited by 12 publications

References 29 publications

Does corticosterone regulate the onset of breeding in free-living birds?: The CORT-Flexibility Hypothesis and six potential mechanisms for priming corticosteroid function

Does corticosterone regulate the onset of breeding in free-living birds?: The CORT-Flexibility Hypothesis and six potential mechanisms for priming corticosteroid function

Fasting Increases Aggression and Differentially Modulates Local And Systemic Steroid Levels in Male Zebra Finches

Determinants and significance of corticosterone regulation in the songbird brain

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