1994
DOI: 10.1126/science.8178155
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Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

Abstract: A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor. Show more

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Cited by 1,357 publications
(1,178 citation statements)
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“…IL-15 was ®rst characterized for its ability to stimulate the proliferation of the murine IL-2-dependent lymphoid cell line CTLL2. It was subsequently shown that IL-15 mimics many other functional properties of IL-2, including stimulation of LAK activity, GM-CSF and IFNg secretion by NK cells as well as proliferation of T, B, and NK cells (Bamford et al, 1994;Grabstein et al, 1994;Carson et al, 1994Carson et al, , 1996Armitage et al, 1995;Gamero et al, 1995). Despite these overlapping activities IL-15 does not share sequence homology with IL-2, even if both cytokines belong to the four a helices cytokine and share the b and g receptor subunits .…”
Section: Introductionmentioning
confidence: 99%
“…IL-15 was ®rst characterized for its ability to stimulate the proliferation of the murine IL-2-dependent lymphoid cell line CTLL2. It was subsequently shown that IL-15 mimics many other functional properties of IL-2, including stimulation of LAK activity, GM-CSF and IFNg secretion by NK cells as well as proliferation of T, B, and NK cells (Bamford et al, 1994;Grabstein et al, 1994;Carson et al, 1994Carson et al, , 1996Armitage et al, 1995;Gamero et al, 1995). Despite these overlapping activities IL-15 does not share sequence homology with IL-2, even if both cytokines belong to the four a helices cytokine and share the b and g receptor subunits .…”
Section: Introductionmentioning
confidence: 99%
“…Both cytokines are therefore mutually exclusive in their production in various cell types [34]. Even though their amino acid sequence shows no homology [34,36], the biological action of both proteins seems to be similar as activators of CD4 + and CD8 + T lymphocytes, gd T cells, NK cells and B lymphocytes [40][41][42][43][44][45][46]. This could be explained by the observation that both IL-2 and IL-15 bind to the IL-2R b-and g cchain [34,36].…”
Section: Introductionmentioning
confidence: 99%
“…Even though their amino acid sequence shows no homology [34,36], the biological action of both proteins seems to be similar as activators of CD4 + and CD8 + T lymphocytes, gd T cells, NK cells and B lymphocytes [40][41][42][43][44][45][46]. This could be explained by the observation that both IL-2 and IL-15 bind to the IL-2R b-and g cchain [34,36]. Binding affinity of both cytokines to the IL-2R subunits and the number of high affinity receptors on activated human peripheral blood mononuclear cells (PBMC) seems to be similar as well [34].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…IL-15 was initially identified as a cytokine that could support the proliferation of an IL-2 dependent cell line in the presence of neutralizing antibodies against IL-2 [103,104]. Some similarities in the in vitro activities of IL-2 and IL-15 are mediated by a shared receptor subunit [105]; however studies in mice lacking IL-15 [106] or IL-2 [107] suggest that the two cytokines mediate distinct biological functions [108].…”
Section: Rantesmentioning
confidence: 99%