“…These include lasR, a global regulator of protease production (Gambello et al, 1993), agmR, which is involved in regulation of glycerol metabolism genes (Po and Schweizer, 1993), anr, an oxygen responsive regulator (Sawers, 1991), fur, which regulates gene expression in response to iron levels (Prince et al, 1991;Prince, 1992), vfr, a cyclic AMP receptor homologue, (West et al, 1994), and most recently pvdS, an alternative sigma factor that regulates production of both iron uptake genes and ETA production (Ochsner et al, 1996). The regAB locus has the greatest and most direct effect on production of ETA (Hedstrom et al, 1986;Hindahl et al, 1987;Frank and Iglewski, 1988;Frank et al, 1989;Storey et al, 1991). The regA gene was cloned by complementation of a chemical mutant of P. aeruginosa defective in production of ETA, PA103-29 (Hedstrom et al, 1986).…”