Cloning of a cDNA for <i>Xenopus</i> prolactin receptor and its metamorphic expression profile

Yamamoto, Takashi; Nakayama, Yuki; Tajima, Tatsuya; Abe, Shinichi; Kawahara, Akira

doi:10.1046/j.1440-169x.2000.00496.x

Cited by 22 publications

(15 citation statements)

References 45 publications

(69 reference statements)

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“…In X. laevis, the values of PRL specific binding to the membranes from the skin were decreased by dehydration of the animals (Muccioli et al 1989). Yamamoto et al (2000) investigated the tissue distribution of PRLR mRNA in adult and larval X. laevis by northern hybridization. In adult tissues, high level expression was found in the lung, heart, brain, thymus and skin, and low level in the oviduct, kidney and spinal cord.…”

Section: Discussionmentioning

confidence: 99%

“…More than 200 effects of prolactin have been documented on growth, reproduction, osmoregulation, and immunologic response (Schardin & Anzenberger 1999). In amphibians, prolactin participates in processes regulating growth, metamorphosis, osmoregulation and re-production (Iwata et al 2000;Yamamoto et al 2000;Takada & Hokari 2007). Studies with exogenous PRL treatment in amphibians have shown changes in skin permeability (Brown et al 1991;Takada 2005;Takada & Hokari 2007), and in skin morphology and secretory activity (Dent 1975;Hoffman & Dent 1978;Singhas & Ward 1993).…”

Section: Introductionmentioning

confidence: 99%

“…In adult amphibian skin, PRLR has been detected by using different methods (D'Istria et al 1987;Muccioli et al 1989;Yamamoto et al 2000;Li et al 2006), although there is a lack of knowledge concerning localization of PRLR in the skin components. In this study, by using an immunohistochemical technique, we have investigated the localization and distribution of PRLR in the dorsal and ventral skin of Rana ridibunda Pallas, 1771 and discussed possible functions of PRL in different skin regions of the body.…”

Section: Introductionmentioning

confidence: 99%

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Localization of prolactin receptor in the dorsal and ventral skin of the frog (Rana ridibunda)

et al. 2010

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Abstract:The dorsal and ventral skin in amphibians plays an important role in osmoregulation. Prolactin hormone is involved in regulation of amphibian skin functions, such as water and electrolyte balance. Therefore, amphibians may be useful as a model for determining the sites of the prolactin receptor. In this study, prolactin receptor was detected in frog dorsal and ventral skin using immunohistochemical staining method. Prolactin receptor immunoreactivity was localized in all epidermal layers except stratum corneum of dorsal skin epidermis, stratum germinativum layer of ventral skin epidermis, myoepithelial cells, secretory epithelium and secretory channel cells of granular glands in both skin regions. The mucous glands and secretory granules of granular glands did not show immunoreactivity for the prolactin receptor. According to our immunohistochemical results, the more widespread detection of prolactin receptor in dorsal skin epidermis indicates that prolactin is more effective in dorsal skin. Presence of prolactin receptors in epidermis points out its possible osmoregulatory effect. Moreover, detection of receptor immunoreactivity in various elements of poison glands in the dermis of both dorsal and ventral skin regions suggests that prolactin has a regulatory effect in gland functions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Localization of prolactin receptor in the dorsal and ventral skin of the frog (Rana ridibunda)

et al. 2010

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“…However, it is actually lower in the larval stages and increases during the climax stages of metamorphosis (Yamamoto and Kikuyama, 1982). In addition, the mRNA for the PRL receptor increases during metamorphosis (Yamamoto et al, 2000). On this basis, PRL seems unlikely to be the juvenile hormone, and other hormone(s) have been proposed for this role (Huang and Brown, 2000a,b;Yamamoto et al, 2000).…”

mentioning

confidence: 99%

“…In addition, the mRNA for the PRL receptor increases during metamorphosis (Yamamoto et al, 2000). On this basis, PRL seems unlikely to be the juvenile hormone, and other hormone(s) have been proposed for this role (Huang and Brown, 2000a,b;Yamamoto et al, 2000).…”

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confidence: 99%

Growth hormone is a weaker candidate than prolactin for the hormone responsible for the development of a larval-type feature in cultured bullfrog skin

Takada

Kasai

2003

Journal of Experimental Biology

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SUMMARYProlactin (PRL) has, for some years, been considered to be the `juvenile hormone' in amphibians. Recently, growth hormone (GH) has been proposed as another candidate, because in the larval stages the expression of the mRNA GH is high but it is downregulated in the climax stages of metamorphosis or following treatment with thyroid hormone. In the present study, we investigated whether GH promotes the development of one particular larval-type feature of bullfrog tadpole skin in vitro. The amiloride-,acetylcholine- and ATP-stimulated short-circuit current (SCC) is a physiological marker of larval-type bullfrog skin. These types of ligand-stimulated SCC (1) developed when EDTA-treated tadpole skin was cultured with corticoids supplemented with PRL or GH and (2) were not significantly different between skin cultured with PRL and intact tadpole skin. However, the amiloride-induced SCC response in skin cultured with GH differed in its kinetics from that of the intact (control) tadpole. On this basis, PRL seems a better candidate than GH for the juvenile hormone, at least with regard to the development of amiloride-stimulated non-selective cation channels.

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Activity and expression of Xenopus laevis matrix metalloproteinases: Identification of a novel role for the hormone prolactin in regulating collagenolysis in both amphibians and mammals

Jung¹,

West‐Mays²,

Stramer³

et al. 2004

Journal Cellular Physiology

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Prolactin (PRL) has long been implicated in Xenopus metamorphosis as an anti-metamorphic and/or juvenilizing hormone. Numerous studies showed that PRL could prevent effects of either endogenous or exogenous thyroid hormone (TH; T(3)). It has been shown that expression of matrix metalloproteinases (MMPs) is induced by TH during Xenopus metamorphosis. Direct in vivo evidence, however, for such anti-TH effects by PRL with respect to MMPs has not been available for the early phase of Xenopus development or metamorphosis. To understand the functional role of PRL, we investigated effects of PRL on Xenopus collagenase-3 (XCL3) and collagenase-4 (XCL4) expression in a cultured Xenopus laevis cell line, XL-177. Northern blot analysis demonstrated that XCL3 and XCL4 expression were not detected in control or T(3)-treated cells, but were differentially induced by PRL in a dose- and time-dependent fashion. Moreover, treatment with IL-1alpha as well as phorbol myristate acetate (PMA), a protein kinase C (PKC) activator, or H8, a protein kinase A (PKA) inhibitor, augmented PRL-induced collagenase expression, suggesting that multiple protein kinase pathways and cytokines may participate in PRL-induced collagenase expression. Interestingly, XCL3 expression could be induced in XL-177 cells by T(3), but only when co-cultured with prometamorphic Xenopus tadpole tails (stage 54/55), suggesting that the tails secrete a required intermediate signaling molecule(s) for T(3)-induced XCL3 expression. Taken together, these data demonstrate that XCL3 and XCL4 can be differentially induced by PRL and T(3) and further suggest that PRL is a candidate regulator of TH-independent collagenase expression during the organ/tissue remodeling which occurs in Xenopus development.

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Cloning of a cDNA for Xenopus prolactin receptor and its metamorphic expression profile

Abstract: A pituitary hormone, prolactin (PRL) shows various effects on cellular metabolism in amphibians

Cited by 22 publications

References 45 publications

Localization of prolactin receptor in the dorsal and ventral skin of the frog (Rana ridibunda)

Localization of prolactin receptor in the dorsal and ventral skin of the frog (Rana ridibunda)

Growth hormone is a weaker candidate than prolactin for the hormone responsible for the development of a larval-type feature in cultured bullfrog skin

Activity and expression of Xenopus laevis matrix metalloproteinases: Identification of a novel role for the hormone prolactin in regulating collagenolysis in both amphibians and mammals

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