Abstract:Mycobacterium tuberculosis (M. tuberculosis) is the causative agent of tuberculosis in human. One of the major M. tuberculosis virulence factors is early secretory antigenic target of 6-kDa (ESAT-6), and EccB 5 protein encoded by eccB 5 is one of its components. EccB 5 protein is a transmembrane protein in ESX-5 system. The aim of this study is to explore the characteristics of wild-type EccB 5 and its mutant form N426I. We expressed the EccB 5 protein by cloning the mutant and wild-type eccB 5 gene in Escheri… Show more
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