Cloning and physical mapping of Yaba monkey tumor virus DNA

Kilpatrick, David R.; Rouhandeh, H.

doi:10.1016/0042-6822(85)90380-0

Cited by 10 publications

(5 citation statements)

References 18 publications

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“…Less conserved OX2 homologues are also found in both HHV-6 (U85) (Gompels et al, 1995) and HHV-7 (U85) (Nicholas, 1996), as well as in several members of the family Poxviridae (Cameron et al, 1999;Kilpatrick & Rouhandeh, 1985;Lee et al, 2001;Tulman et al, 2001;Willer et al, 1999). A phylogenetic analysis of OX2 protein sequences from KSHV K14, HHV-7 and RCMV-E revealed that there is no reason to suggest that there is any collinearity between the three viral OX2 genes and they appear to have been captured and evolved independently of one another, with the RCMV-E version retaining the greatest similarity to the cellular versions (therefore being the most recently captured?…”

Section: Discussionmentioning

confidence: 99%

The English strain of rat cytomegalovirus (CMV) contains a novel captured CD200 (vOX2) gene and a spliced CC chemokine upstream from the major immediate-early region: further evidence for a separate evolutionary lineage from that of rat CMV Maastricht

Voigt

Sandford

Hayward

et al. 2005

Journal of General Virology

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The English strain of rat cytomegalovirus (CMV) contains a novel captured CD200 (vOX2) gene and a spliced CC chemokine upstream from the major immediate-early region: further evidence for a separate evolutionary lineage from that of rat CMV Maastricht Sequence data for eight genes, together with time-course Northern blotting and 39-and 59-RACE (rapid amplification of cDNA ends) analysis for some mRNAs from a 12 kb region upstream from the major immediate-early (MIE) genes of the English isolate of rat cytomegalovirus (RCMV), are presented. The results identified important differences compared to both murine cytomegalovirus (MCMV) and the Maastricht isolate of RCMV. A striking finding is the presence of a highly conserved, rightwards-oriented homologue of the rat cellular CD200 (OX2) gene immediately to the right of the MIE region, which replaces either the leftwards-oriented AAV REP gene of RCMV (Maastricht) or the upstream spliced portions of the immediate-early 2 gene (ie2) in MCMV. From the presence of other homologues of MCMV-and RCMV-specific genes, such as the b-chemokine MCK-2, SGG1 and an Fcc receptor gene, as reported here, the basic architecture of the MIE region (reported previously) and the level of IE2 and DNA polymerase (POL) protein conservation in phylogenetic analyses, it is clear that the English strain of RCMV is also a member of the genus Muromegalovirus, but is a b-herpesvirus species that is very distinct from both MCMV and RCMV (Maastricht). Both the lack of a CD200 homologue in the other two rodent viruses and the depth of sequence divergence of the rodent CMV IE2 and POL proteins suggest that these three viruses have evolved as separate species in the genus Muromegalovirus since very early in the host rodent lineage.

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Section: Discussionmentioning

confidence: 99%

The English strain of rat cytomegalovirus (CMV) contains a novel captured CD200 (vOX2) gene and a spliced CC chemokine upstream from the major immediate-early region: further evidence for a separate evolutionary lineage from that of rat CMV Maastricht

Voigt

Sandford

Hayward

et al. 2005

Journal of General Virology

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“…Interestingly, several viruses contain a homologue of cellular OX2. These include KSHV K14 (7), RRV R14 (8,45), human herpesvirus 6 U85 (16), human herpesvirus 7 U85 (34), Shope fibroma virus S141R (47), myxoma virus M141R (4), Yaba-like disease virus 140R (27), and Yaba monkey tumor virus Yb-C2R (24). Because of the diversity of these viruses, it appears that they might have independently captured the cellular OX2 gene and that the presence of OX2 homology may provide a significant selective advantage to viruses during coevolution with the host.…”

Section: Discussionmentioning

confidence: 99%

Kaposi's Sarcoma-Associated Herpesvirus OX2 Glycoprotein Activates Myeloid-Lineage Cells To Induce Inflammatory Cytokine Production

Chung

Means

Choi

et al. 2002

J Virol

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Kaposi's sarcoma is an inflammatory cytokine-mediated angioproliferative disease which is triggered by infection by Kaposi's sarcoma-associated herpesvirus (KSHV). KSHV contains an open reading frame, K14, that has significant homology with cellular OX2, designated viral OX2 (vOX2). In this report, we demonstrate that vOX2 encodes a glycosylated cell surface protein with an apparent molecular mass of 55 kDa. Purified glycosylated vOX2 protein dramatically stimulated primary monocytes, macrophages, and dendritic cells to produce the inflammatory cytokines interleukin 1␤ (IL-1␤), IL-6, monocyte chemoattractant protein 1, and TNF-␣. Furthermore, expression of vOX2 on B lymphocytes stimulated monocytes to produce inflammatory cytokines in mixed culture. These results demonstrate that like its cellular counterpart, vOX2 targets myeloidlineage cells, but unlike cellular OX2, which delivers a restrictive signal, KSHV vOX2 provides an activating signal, resulting in the production of inflammatory cytokines. Thus, this is a novel viral strategy where KSHV has acquired the cellular OX2 gene to induce inflammatory cytokine production, which potentially promotes the cytokine-mediated angiogenic proliferation of KSHV-infected cells.

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“…2). The restriction sites of the Yaba virus DNA were partly different from those published by Kilpatrick & Rouhandeh (1985, although the virus strain used in this study was apparently the same. The reason for this discrepancy is not known but may involve differences in the passage history of the virus.…”

Section: Discussionmentioning

confidence: 38%

Identification and characterization of the thymidine kinase gene of Yaba virus

Amano

Ueda

Miyamura

1995

Journal of General Virology

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DNA of Yaba virus, a member of the poxviruses, was mapped by cross-hybridization between fragments of various restriction enzymes. The genome was approximately 13 5 kb in length and possessed two characteristic features of poxviruses: cross-links and inverted terminal repeats at both termini. Hybridization of fragments of Yaba virus DNA to known vaccinia virus DNA fragments indicated that the thymidine kinase (TK) gene mapped within the 0.9 kb XhoI-HincII fragment between 52"5 and 53'5 kb from the left end of the genome. The fragment could rescue the TK + phenotype in TK cells preinfected with a TK vaccinia virus mutant. Nucleotide sequencing of the fragment revealed an ORF capable of encoding 181 amino acids. The sequence TAAAAATG-AAAAATTA upstream of the ORF was considered to be the promoter and the downstream sequence TTTT-TAT to be the early transcription termination signal. These sequences are in good accord with the consensus regulatory sequences for the expression of early genes of other known poxviruses. The amino acid sequence similarity among the poxvirus TK genes suggests that Yaba virus is most closely related to swinepox virus and less similar to fowlpox virus.

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Cloning and physical mapping of Yaba monkey tumor virus DNA

Cited by 10 publications

References 18 publications

The English strain of rat cytomegalovirus (CMV) contains a novel captured CD200 (vOX2) gene and a spliced CC chemokine upstream from the major immediate-early region: further evidence for a separate evolutionary lineage from that of rat CMV Maastricht

The English strain of rat cytomegalovirus (CMV) contains a novel captured CD200 (vOX2) gene and a spliced CC chemokine upstream from the major immediate-early region: further evidence for a separate evolutionary lineage from that of rat CMV Maastricht

Kaposi's Sarcoma-Associated Herpesvirus OX2 Glycoprotein Activates Myeloid-Lineage Cells To Induce Inflammatory Cytokine Production

Identification and characterization of the thymidine kinase gene of Yaba virus

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