Cloning and mapping of murine Nfe2l1

McKie, J; Johnstone, Karen A.; Matteï, Marie‐Geneviève; Scambler, Peter J.

doi:10.1016/0888-7543(95)80015-e

Cited by 29 publications

(25 citation statements)

References 14 publications

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“…Our mapping results confirm unpublished radiation hybrid localization data (Jackson Laboratory, MGI:1339958). As has been reported for other CNC transcription factor loci (10,32,40,41,63), the mouse Nrf3 gene colocalizes with members of the Hox and collagen gene families. Gene targeting of the mouse Nrf3 locus.…”

Section: Resultsmentioning

confidence: 68%

“…This mapping result further strengthens the hypothesis, proposed previously (10,32), that the genetic loci of p45, Nrf1, Nrf2, and Nrf3 have evolved from a single gene. Mouse and human versions of these genes colocalize to a cluster of genes comprising members of the collagen and Hox gene families (10,32,40,41,63). The p45 (human, 12q13.1-13.3; mouse, 15), Nrf1 (human, 17q21.3; mouse, 11), Nrf2 (human, 2q31; mouse, 2), and Nrf3 (human, 7p14-15; mouse, 6) genes map to each of the four known hox clusters, hoxC, hoxB, hoxD, and hoxA, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the Nrf3 Locus

Derjuga¹,

Gourley

Holm

et al. 2004

Molecular and Cellular Biology

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Cap'n'collar (CNC) family basic leucine zipper transcription factors play crucial roles in the regulation of mammalian gene expression and development. To determine the in vivo function of the CNC protein Nrf3 (NF-E2-related factor 3), we generated mice deficient in this transcription factor. We performed targeted disruption of two Nrf3 exons coding for CNC homology, basic DNA-binding, and leucine zipper dimerization domains. Nrf3 null mice developed normally and revealed no obvious phenotypic differences compared to wild-type animals. Nrf3 ؊/؊ mice were fertile, and gross anatomy as well as behavior appeared normal. The mice showed normal age progression and did not show any apparent additional phenotype during their life span. We observed no differences in various blood parameters and chemistry values. We infected wild-type and Nrf3 ؊/؊ mice with acute lymphocytic choriomeningitis virus and found no differences in these animals with respect to their number of virus-specific CD8 and CD4 T cells as well as their B-lymphocyte response. To determine whether the mild phenotype of Nrf3 null animals is due to functional redundancy, we generated mice deficient in multiple CNC factors. Contrary to our expectations, an absence of Nrf3 does not seem to cause additional lethality in compound Nrf3 ؊/؊ /Nrf2 ؊/؊ and Nrf3 ؊/؊ /p45 ؊/؊ mice. We hypothesize that the role of Nrf3 in vivo may become apparent only after appropriate challenge to the mice.

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Section: Resultsmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the Nrf3 Locus

Derjuga¹,

Gourley

Holm

et al. 2004

Molecular and Cellular Biology

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“…Nrf1 maps to chromosome 17q21.3 in human and chromosome 11 in mouse (Chan et al , 1995; McKie et al , 1995). In humans, the Nrf1 gene which spans 15 kb of genomic DNA, and has 9 exons with alternate first exons (1a and 1b) and terminal exons (6 and 6a), and 2 polyadenylation sites (Luna et al , 1994).…”

Section: Structure and Properties Of Nrf1mentioning

confidence: 99%

Role of Nrf1 in antioxidant response element-mediated gene expression and beyond

Biswas

Chan

2010

Toxicology and Applied Pharmacology

185

149

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Oxidative stress plays an important part in the pathogenesis of a variety of diseases. The ability to mount an efficient response against the continuous threat posed by exogenous and endogenous oxidants is essential for cellular homeostasis and survival. Oxidative stress activates transcription of a variety of antioxidant genes through cis-acting sequence known as antioxidant response element (ARE). Members of the Cap-N-Collar family of transcription factors, including Nrf1 and Nrf2, have been identified that bind ARE. Nrf1 and Nrf2 are expressed in a wide range of tissues and cell types, and both bind the ARE as heterodimers with small-Maf proteins. Numerous studies indicate a pivotal role of Nrf2 in ARE function. Herein, we review data derived from cell-based studies and knockout mice in an attempt to define the role and regulation of Nrf1 in oxidative stress response and other functions.

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“…We and others have sought to identify proteins other than AP‐1 which activate transcription by binding the NF‐E2/AP‐1 motif of HS‐2 in the β‐globin LCR (Orkin, 1990). Several such proteins including p45‐Nf‐e2, Nrf‐1(LCR‐F1/NFE2L1/TCF11) and Nrf‐2(ECH) have been identified to date (Andrews et al ., 1993; Chan et al ., 1993a; Ney et al ., 1993; Caterina et al ., 1994; Moi et al ., 1994; Chui et al ., 1995; Itoh et al ., 1995; McKie et al ., 1995). These proteins are members of a subset of bZIP genes sharing a conserved structural domain, termed the ‘CNC’ domain, first noted in the Drosophila cap and collar (CNC) gene which is required for labial and mandibular development (Mohler et al ., 1991, 1995).…”

Section: Introductionmentioning

confidence: 99%

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice

et al. 1998

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The CNC-basic leucine zipper (CNC-bZIP) family is a subfamily of bZIP proteins identified from independent searches for factors that bind the AP-1-like cis-elements in the β-globin locus control region. Three members, p45-Nf-e2, Nrf-1 and Nrf-2 have been identified in mammals. Expression of p45-Nf-e2 is largely restricted to hematopoietic cells while Nrf-1 and Nrf-2 are expressed in a wide range of tissues. To determine the function of Nrf-1, targeted disruption of the Nrf-1 gene was carried out. Homozygous Nrf-1 mutant mice are anemic due to a non-cell autonomous defect in definitive erythropoiesis and die in utero.

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Cloning and mapping of murine Nfe2l1

Cited by 29 publications

References 14 publications

Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the Nrf3 Locus

Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the Nrf3 Locus

Role of Nrf1 in antioxidant response element-mediated gene expression and beyond

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice

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