Abstract:OCT1 and OCT2 are polyspecific membrane transporters that are involved in hepatic and renal drug clearance in humans and mice. In this study, we cloned dog OCT1 and OCT2 and compared their function to the human and mouse orthologs. We used liver and kidney RNA to clone dog OCT1 and OCT2. The cloned and the publicly available RNA-Seq sequences differed from the annotated exon-intron structure of OCT1 in the dog genome CanFam3.1. An additional exon between exons 2 and 3 was identified and confirmed by sequencing… Show more
“…The paper “Cloning and Functional Characterization of Dog OCT1 and OCT2: Another Step in Exploring Species Differences in Organic Cation Transporters” by Meyer at al. [ 3 ] is another important comparative study on the species-specific properties of organic cation transporters (OCTs). Analyzing the sequences of dog organic cation transporter 1 (dog OCT1) and dog OCT2, they found that the correct dog OCT1 sequence differs from the annotated dog genome assembly in the NCBI database (CanFam3.1).…”
This editorial summarizes the 12 scientific papers published in the Special Issue “Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations 2 [...]
“…The paper “Cloning and Functional Characterization of Dog OCT1 and OCT2: Another Step in Exploring Species Differences in Organic Cation Transporters” by Meyer at al. [ 3 ] is another important comparative study on the species-specific properties of organic cation transporters (OCTs). Analyzing the sequences of dog organic cation transporter 1 (dog OCT1) and dog OCT2, they found that the correct dog OCT1 sequence differs from the annotated dog genome assembly in the NCBI database (CanFam3.1).…”
This editorial summarizes the 12 scientific papers published in the Special Issue “Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations 2 [...]
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