Cloning and Functional Analysis of Pax6 from the Hydrothermal Vent Tubeworm Ridgeia piscesae

Yuan, Huifang; Wang, Wei; Hu, Bin; Pan, Changkun; Chen, Mingliang; Ke, Linlin; Yang, Lirong; Chen, Jianming

doi:10.1371/journal.pone.0168579

Cited by 3 publications

(3 citation statements)

References 77 publications

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“…Like Foxg1, Pax6 is highly conserved across the animal kingdom and is essential for normal anterior neural development in both invertebrates and vertebrates (Manuel et al., 2015, Yuan et al., 2016). Unlike Foxg1, however, Pax6 promotes exit from the cell cycle in the mammalian cerebral cortex.…”

Section: Discussionmentioning

confidence: 99%

Tissue-Specific Actions of Pax6 on Proliferation and Differentiation Balance in Developing Forebrain Are Foxg1 Dependent

Quintana‐Urzainqui¹,

Kozić²,

Mitra³

et al. 2018

iScience

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SummaryDifferences in the growth and maturation of diverse forebrain tissues depend on region-specific transcriptional regulation. Individual transcription factors act simultaneously in multiple regions that develop very differently, raising questions about the extent to which their actions vary regionally. We found that the transcription factor Pax6 affects the transcriptomes and the balance between proliferation and differentiation in opposite directions in the diencephalon versus cerebral cortex. We tested several possible mechanisms to explain Pax6's tissue-specific actions and found that the presence of the transcription factor Foxg1 in the cortex but not in the diencephalon was most influential. We found that Foxg1 is responsible for many of the differences in cell cycle gene expression between the diencephalon and cortex and, in cortex lacking Foxg1, Pax6's action on the balance of proliferation versus differentiation becomes diencephalon like. Our findings reveal a mechanism for generating regional forebrain diversity in which one transcription factor completely reverses the actions of another.

show abstract

Section: Discussionmentioning

confidence: 99%

Tissue-Specific Actions of Pax6 on Proliferation and Differentiation Balance in Developing Forebrain Are Foxg1 Dependent

Quintana‐Urzainqui¹,

Kozić²,

Mitra³

et al. 2018

iScience

View full text Add to dashboard Cite

show abstract

“…Like Foxg1, Pax6 is highly conserved across the animal kingdom and is essential for normal anterior neural development in both invertebrates and vertebrates (Manuel et al, 2015;Yuan et al, 2016). Unlike Foxg1, however, Pax6 promotes exit from the cell cycle in the mammalian cerebral cortex.…”

Section: Discussionmentioning

confidence: 99%

Tissue-specific actions of Pax6 on proliferation-differentiation balance in the developing forebrain are Foxg1-dependent

Quintana‐Urzainqui

Kozić

Mitra

et al. 2018

Preprint

View full text Add to dashboard Cite

SummaryDifferences in the growth and maturation of diverse forebrain tissues depends on regionspecific transcriptional regulation. Individual transcription factors act simultaneously in multiple regions that develop very differently, raising questions about the extent to which their actions vary regionally. We found that the transcription factor Pax6 affects the transcriptomes and the balance between proliferation and differentiation in opposite directions in murine diencephalon versus cortex. We tested several possible mechanisms to explain Pax6's tissue-specific actions and found that the presence of the transcription factor Foxg1 in cortex but not diencephalon was most influential. We found that Foxg1 is responsible for many of the differences in cell cycle gene expression between diencephalon and cortex. In cortex lacking Foxg1, Pax6's action on the balance of proliferation versus differentiation became diencephalon-like. Our findings reveal a mechanism for generating regional forebrain diversity in which the actions of one transcription factor completely reverse the actions of another.

show abstract

Section: Discussionmentioning

confidence: 99%

Tissue-Specific Actions of Pax6 on the Balance of Proliferation and Differentiation in Developing Forebrain are Foxg1-Dependent

et al. 2018

View full text Add to dashboard Cite

Differences in the growth and maturation of diverse forebrain tissues depend on region-specific transcriptional regulation. Individual transcription factors act simultaneously in multiple regions that develop very differently, raising questions about the extent to which their actions vary regionally. We found that the transcription factor Pax6 affects the transcriptomes and the balance between proliferation and differentiation in opposite directions in the diencephalon versus cerebral cortex. We tested several possible mechanisms to explain Pax6's tissue-specific actions and found that the presence of the transcription factor Foxg1 in the cortex but not in the diencephalon was most influential. We found that Foxg1 is responsible for many of the differences in cell cycle gene expression between the diencephalon and cortex and, in cortex lacking Foxg1, Pax6's action on the balance of proliferation versus differentiation becomes diencephalon like. Our findings reveal a mechanism for generating regional forebrain diversity in which one transcription factor completely reverses the actions of another.

show abstract

Cloning and Functional Analysis of Pax6 from the Hydrothermal Vent Tubeworm Ridgeia piscesae

Cited by 3 publications

References 77 publications

Tissue-Specific Actions of Pax6 on Proliferation and Differentiation Balance in Developing Forebrain Are Foxg1 Dependent

Tissue-Specific Actions of Pax6 on Proliferation and Differentiation Balance in Developing Forebrain Are Foxg1 Dependent

Tissue-specific actions of Pax6 on proliferation-differentiation balance in the developing forebrain are Foxg1-dependent

Tissue-Specific Actions of Pax6 on the Balance of Proliferation and Differentiation in Developing Forebrain are Foxg1-Dependent

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