Cloning and Expression of a cDNA for a Mammalian Type III Iodothyronine Deiodinase

Croteau, Walburga; Whittemore, Susan; Schneider, Mark J.; Germain, Donald L. St.

doi:10.1074/jbc.270.28.16569

Cited by 181 publications

(71 citation statements)

References 26 publications

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“…Type 2 deiodinase expression in rodent heart is much lower than in human heart (Croteau et at., 1996), therefore rodents are not considered a suitable model for human D2 regulation. Cardiac D2 mRNA and activity in mouse and rats has, however, been demonstrated to respond to changes in thyroid hormone levels induced by hypothyroidism provoked by methimazol treatment (Wagner et al, 2003) or iodine deficiency (Lavado-Autric et al, 2013) and attenuated by T3 administration (Wagner et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

The effects of caloric restriction and age on thyroid hormone signalling in the heart of rats

Lachowicz¹,

Fürstenberg²,

Pałkowska³

et al. 2014

J. Anim. Feed Sci.

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Section: Discussionmentioning

confidence: 99%

The effects of caloric restriction and age on thyroid hormone signalling in the heart of rats

Lachowicz¹,

Fürstenberg²,

Pałkowska³

et al. 2014

J. Anim. Feed Sci.

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“…Poly(A) + RNA was isolated from the total RNA as described previously (18). Northern analysis was carried out as described previously using the NS43-1 rat D3 cDNA as a probe (19). Hybridization was conducted at 42°C with final washes at 55°C (18).…”

Section: Methodsmentioning

confidence: 99%

Pregnant rat uterus expresses high levels of the type 3 iodothyronine deiodinase

Galton¹,

Bueno-Martínez²,

Hernández³

et al. 1999

J. Clin. Invest.

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139

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Although thyroid hormones are critically important for the coordination of morphogenic processes in the fetus and neonate, premature exposure of the embryo to levels of the hormones present in the adult is detrimental and can result in growth retardation, malformations, and even death. We report here that the pregnant rat uterus expresses extremely high levels of the type 3 iodothyronine deiodinase (D3), which inactivates thyroxine and 3,3′,5-triiodothyronine by 5-deiodination. Both D3 mRNA and activity were present at the implantation site as early as gestational day 9 (E9), when expression was localized using in situ hybridization to uterine mesometrial and antimesometrial decidual tissue. At later stages of gestation, uterine D3 activity remained very high, and the levels exceeded those observed in the placenta and in fetal tissues. After days E12 and E13, as decidual tissues regressed, D3 expression became localized to the epithelial cells lining the recanalized uterine lumen that surrounds the fetal cavity. These findings strongly suggest that the pregnant uterus, in addition to the placenta, plays a critical role in determining the level of exposure of the fetus to maternal thyroid hormones.J. Clin. Invest. 103:979-987 (1999).

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“…The metabolic activation (Behne et al, 1990;Arthur et al, 1990;Davey et al, 1995), as well as degradation of thyroid hormones (Croteau et al, 1995), were shown to depend on selenium-containing deiodinases. Most surprisingly, selenium was also discovered in a well-documented enzyme of basic metabolic relevance, in thioredoxin reductase (Tamura and Stadtman, 1996).…”

Section: Introduction: Some Historical Landmarksmentioning

confidence: 99%

Selenium in Biology: Facts and Medical Perspectives

Köhrl¹,

Brigelius‐Flohé²,

Böck³

et al. 2000

Biological Chemistry

245

143

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Several decades after the discovery of selenium as an essential trace element in vertebrates approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the 21 st proteinogenic amino acid, selenocysteine, have been identified, partially characterized or cloned from several species. Many of these proteins are involved in redox reactions with selenocysteine acting as an essential component of the catalytic cycle. Enzyme activities have been assigned to the glutathione peroxidase family, to the thioredoxin reductases, which were recently identified as selenoproteins, to the iodothyronine deiodinases, which metabolize thyroid hormones, and to the selenophosphate synthetase 2, which is involved in selenoprotein biosynthesis. Prokaryotic selenoproteins catalyze redox reactions and formation of selenoethers in (stress-induced) metabolism and energy production of E. coli, of the clostridial cluster XI and of other prokaryotes. Apart from the specific and complex biosynthesis of selenocysteine, selenium also reversibly binds to proteins, is incorporated into selenomethionine in bacteria, yeast and higher plants, or posttranslationally modifies a catalytically essential cysteine residue of CO dehydrogenase. Expression of individual eukaryotic selenoproteins exhibits high tissue specificity, depends on selenium availability, in some cases is regulated by hormones, and if impaired contributes to several pathological conditions. Disturbance of selenoprotein expression or function is associated with deficiency syndromes (Keshan and Kashin-Beck disease), might contribute to tumorigenesis and atherosclerosis, is altered in several bacterial and viral infections, and leads to infertility in male rodents.

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Cloning and Expression of a cDNA for a Mammalian Type III Iodothyronine Deiodinase

Cited by 181 publications

References 26 publications

The effects of caloric restriction and age on thyroid hormone signalling in the heart of rats

The effects of caloric restriction and age on thyroid hormone signalling in the heart of rats

Pregnant rat uterus expresses high levels of the type 3 iodothyronine deiodinase

Selenium in Biology: Facts and Medical Perspectives

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