Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia

Morelli, Cristina; Magnanini, Chiara; Mungall, Andrew J.; Negrini, Massimo; Barbanti‐Brodano, Giuseppe

doi:10.1016/s0378-1119(00)00231-6

Cited by 22 publications

(16 citation statements)

References 26 publications

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“…Until recently, it was believed that they occur much less frequently in eukaryotic nuclear genomes. Although their presence in human and other species' genomes was reported previously (Williams and Fried 1986;Lazar et al 1989;Miyajima et al 1989;Burke et al 1998;Cooper et al 1998;Bachman et al 1999;Shintani et al 1999;Misener and Walker 2000;Morelli et al 2000;Slavov et al 2000;Zhuo et al 2001), until lately very little was known about their frequency and genome-wide distribution. Recent reports show that overlapping genes occur relatively frequently in human and other mammalian genomes (Kiyosawa and Abe 2002;Lehner et al 2002;Okazaki et al 2002;Shendure and Church 2002;Yelin et al 2003).…”

mentioning

confidence: 92%

Mammalian Overlapping Genes: The Comparative Perspective

Veeramachaneni¹,

Makałowski²,

Galdzicki³

et al. 2004

Genome Res.

128

130

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It is believed that 3.2 billion bp of the human genome harbor ∼35,000 protein-coding genes. On average, one could expect one gene per 300,000 nucleotides (nt). Although the distribution of the genes in the human genome is not random,it is rather surprising that a large number of genes overlap in the mammalian genomes. Thousands of overlapping genes were recently identified in the human and mouse genomes. However,the origin and evolution of overlapping genes are still unknown. We identified 1316 pairs of overlapping genes in humans and mice and studied their evolutionary patterns. It appears that these genes do not demonstrate greater than usual conservation. Studies of the gene structure and overlap pattern showed that only a small fraction of analyzed genes preserved exactly the same pattern in both organisms

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mentioning

confidence: 92%

Mammalian Overlapping Genes: The Comparative Perspective

Veeramachaneni¹,

Makałowski²,

Galdzicki³

et al. 2004

Genome Res.

128

130

View full text Add to dashboard Cite

show abstract

“…TRAF3IP2 encodes Act1 (transcription factor NF-κB activator 1), also known as CIKS (Connection to IKK and SAPK/JNK) (Leonardi et al, 2000, Li et al, 2000, Morelli et al, 2000). Act1 is recruited to the IL-17 receptor through a SEFIR domain-mediated oligomerization and is essential for appropriate regulation of IL-17-mediated signaling (Chang et al, 2006, Qian et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Dual Role of Act1 in Keratinocyte Differentiation and Host Defense: TRAF3IP2 Silencing Alters Keratinocyte Differentiation and Inhibits IL-17 Responses

Lambert

Tsoi

Stoll

et al. 2017

Journal of Investigative Dermatology

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TRAF3IP2 is a candidate psoriasis susceptibility gene encoding Act1, an adaptor protein with ubiquitin ligase activity that couples the IL-17 receptor to downstream signaling pathways. We investigated the role of Act1 in keratinocyte responses to IL-17 using a tetracycline inducible shRNA targeting TRAF3IP2. Tet exposure for seven days effectively silenced TRAF3IP2 mRNA and Act1 protein, resulting in 761 genes with significant changes in expression (495 down, 266 up, >1.5-fold, p<0.05). Gene Ontology analysis revealed that genes affected by TRAF3IP2 silencing are involved in epidermal differentiation, with early differentiation genes (KRT1, KRT10, DSC1, DSG1) being downregulated and late differentiation genes (SPRR2, SPRR3, LCE3) being upregulated. AP1 binding sites were enriched upstream of genes up-regulated by TRAF3IP2 silencing. Correspondingly, nuclear expression of FosB and Fra1 was increased in TRAF3IP2-silenced cells. Many genes involved in host defense were induced by IL-17 in a TRAF3IP2-dependent fashion. Inflammatory differentiation conditions (serum addition for 4 days postconfluence) markedly amplified these IL-17 responses, while increasing basal levels and TRAF3IP2 silencing-dependent upregulation of multiple late differentiation genes. These findings suggest that TRAF3IP2 may alter both epidermal homeostasis and keratinocyte defense responses to influence psoriasis risk.

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“…Schizophrenia spectrum disorders have also been linked to the reelin ( RELN ) gene and its antisense transcript HAR1 (Tamura et al , 2007). Other lncRNAs have been reported to be implicated in SZ, including C6UAS (Morelli et al , 2000) and LINC00271 (Amann-Zalcenstein et al , 2006). …”

Section: Roles Of Lncrnas In Psychiatric Disordersmentioning

confidence: 99%

Long noncoding RNAs in psychiatric disorders

Zuo

Tan

Wang

et al. 2016

Psychiatric Genetics

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Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. Many of these lncRNAs have regulatory functions and have recently emerged as major players in governing fundamental biological processes. Here we review the definition, distribution, identification, databases, analysis, classification and functions of lncRNAs. We also discuss the potential roles of lncRNAs in the etiological processes of psychiatric disorders and the implications for clinical diagnosis and treatment.

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Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia

Cited by 22 publications

References 26 publications

Mammalian Overlapping Genes: The Comparative Perspective

Mammalian Overlapping Genes: The Comparative Perspective

Dual Role of Act1 in Keratinocyte Differentiation and Host Defense: TRAF3IP2 Silencing Alters Keratinocyte Differentiation and Inhibits IL-17 Responses

Long noncoding RNAs in psychiatric disorders

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