Cloning and characterization of the murine homolog of thesno proto-oncogene reveals a novel splice variant

Pelzer, Theo; Lyons, Gary E.; Kim, Stuart; Moreadith, Randall W.

doi:10.1002/(sici)1097-0177(199602)205:2<114::aid-aja3>3.0.co;2-l

Cited by 27 publications

(9 citation statements)

References 27 publications

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“…Further research is needed to verify this idea and to define the full length sequences of these proteins. trovirus [40][41][42][43][44][45][46]. Recently, a number of genes have been classified as homologs of sno and ski, including dach1 and dach2, the mammalian orthologs of Drosophila dachshund that functions in regulating eye and leg development, dach-like novel gene (DLN1), the mammalian ortholog of Xenopus dachshund-like with gill expression (xDawg), the functional smad suppressing element genes on chromosomes 15 or 18 , and corl1 (Lbxcor1) and corl2, the corepressors for the mammalian homolog of Drosophila ladybird homeobox 1 [47][48][49][50][51][52][53][54][55][56][57][58][59][60].…”

Section: Sno Is a Member Of The Ski/sno/dac Gene Familymentioning

confidence: 99%

“…sno and ski are expressed in most embryonic and adult-derived tissues including brain, skeletal muscle, and heart [44,45,[63][64][65]. In contrast, corl1, Fussel-15 and Fussel-18 expression is detected mainly in the testis and specific regions of the nervous system during embryogenesis and homeostasis [55,57,58].…”

Section: Corl/fusselmentioning

confidence: 99%

“…The relationship between the Sno isoforms is described in Fig. (2) and elsewhere [41,[43][44][45]. SnoN is the main isoform in human cells.…”

Section: Corl/fusselmentioning

confidence: 99%

“…SnoN is the main isoform in human cells. In contrast, mouse cells express more SnoN2 than SnoN except in the brain, eye and heart where these two isoforms are approximately equally expressed [44,45]. Interestingly, the SnoN isoform is the only reported sno gene product in chicken-derived mRNA, while Drosophila has been proposed to produce homologous sequences to all four human isoforms [42,59,66].…”

Section: Corl/fusselmentioning

confidence: 99%

“…The first 366 amino acid residues of SnoA are identical to the corresponding region in other Sno isoforms, whereas the last 49 residues are unique to this isoform (denoted by a striped bar). SnoI is a truncated version of SnoN and is generated by alternative splicing of exon 3. sno gene products are expressed in muscle tissues, suggesting a role for this gene in muscle differentiation [43,44]. Consistent with this idea, SnoN regulates skeletal muscle differentiation in a concentration-dependent manner, and this function of SnoN also appears to be regulated by its sumoylation status [108, 109 and see below].…”

Section: Snon Regulates Several Biological Responsesmentioning

confidence: 99%

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SnoN in TGF-β Signaling and Cancer Biology

Pot¹,

Bonni

2008

CMM

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The Transforming Growth Factor (TGF)- beta-Smad signaling pathway regulates diverse biological processes essential for normal development and homeostasis. The Smad-interacting transcriptional modulator SnoN and its related homologs have emerged as important modulators of TGF-beta signaling and responses. SnoN forms a physical complex with the TGF-beta-regulated Smad2/Smad3 and co-Smad4 proteins and either represses or stimulates TGF-beta-induced Smad-dependent transcription in a cell- and promoter-specific manner. In addition, the TGF-beta-activated Smads recruit several ubiquitin ligases to SnoN and thereby promote the ubiquitination and consequent degradation of SnoN. Additional modifications of SnoN, including sumoylation, may contribute to the regulation of SnoN function and its role in TGF-beta signaling. Collectively, these studies suggest that SnoN function is intimately linked to the TGF-beta-Smad pathway in cellular signaling. Although the mechanisms by which SnoN modulates signaling in the TGF-beta-Smad pathway are beginning to be characterized, the full range of SnoN functions and underlying mechanisms in normal development and disease processes remains to be elucidated.

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Section: Sno Is a Member Of The Ski/sno/dac Gene Familymentioning

confidence: 99%

Section: Corl/fusselmentioning

confidence: 99%

“…The relationship between the Sno isoforms is described in Fig. (2) and elsewhere [41,[43][44][45]. SnoN is the main isoform in human cells.…”

Section: Corl/fusselmentioning

confidence: 99%

Section: Corl/fusselmentioning

confidence: 99%

Section: Snon Regulates Several Biological Responsesmentioning

confidence: 99%

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SnoN in TGF-β Signaling and Cancer Biology

Pot¹,

Bonni

2008

CMM

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Myocardial Cell Signaling During the Transition to Heart Failure

Zeglinski

Moghadam

Ande

et al. 2018

Comprehensive Physiology

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Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. This review summarizes the signaling pathways implicated in the transition to HF following cardiac injury. In addition, we provide an update on cell death signaling and discuss recent advances in cardiac fibrosis as an independent event leading to HF. Finally, we discuss cell‐based therapies and their possible use to avert the deteriorating nature of HF. © 2019 American Physiological Society. Compr Physiol 9:75‐125, 2019.

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