Cloning and Characterization of the Nucleoredoxin Gene That Encodes a Novel Nuclear Protein Related to Thioredoxin

Nucleoredoxin Negatively Regulates Toll-like Receptor 4 Signaling via Recruitment of Flightless-I to Myeloid Differentiation Primary Response Gene (88)

“…NRX is ubiquitously expressed with abundant expression in skin, testis, skeletal muscle, and moderately in thymus and spleen (2), whereas RdCVF expression is limited to the retina (28). NRX, therefore, appears to play a general role in regulation of the TLR4/MyD88 pathway, including innate immunity, but RdCVF may play a special role in the retina.…”

Chemogenomic identification of Ref-1/AP-1 as a therapeutic target for asthma

“…Recently, it has become evident that some of the members of this superfamily of oxidoreductases are involved in regulating inflammatory processes. Other members of the oxidoreductase superfamily that may play important roles in inflammatory processes include nucleoredoxin (41), which significantly enhances tumor necrosis factor-␣-induced NF-B reporter activity (42); PICOT, a 37.5-kDa PKC -interacting protein that regulates AP-1 and NF-B transcription (43); and TRP32, a 32-kDa protein that interacts with the catalytic domain of the protein kinase MST (44 …”

Thioredoxin participates in a cell death pathway induced by interferon and retinoid combination

“…Cleavage products were indicated with arrows the sequence, Cys-Gly-Pro-Cys, are necessary for the redox function of thioredoxin (Arner and Holmgren, 2000). Several thioredoxins or thioredoxin-like proteins exist in mammalian cells (Kurooka et al, 1997;Lee et al, 1998b;Spyrou et al, 1997), whose individual physiologic roles have not been clearly understood. The most-well characterized member of these thioredoxins, Trx1, is critical for mammalian development because a homozygous deletion of this gene causes embryonic lethality in mice (Matsui et al, 1996).…”