Cloning and Characterization of Rat Leukotriene B4 Receptor

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

“…2). The BLT 1 R has also been isolated in other species, with a homology similar to that of the human protein in mice (78%; Huang et al, 1998), in guinea pigs (78%; Masuda et al, 1999), and in rats (80%; Toda et al, 1999).…”

“…BLT 1 R expression has also been demonstrated on peritoneal and alveolar macrophages and in RAW 264.7 cells (Huang et al, 1998;Toda et al, 1999). In the latter macrophage cell line, LTB 4 induces increased proliferation and [ 3 H]thymidine uptake, suggesting that LTB 4 may also have mitogenic effects on macrophages (Nieves and Moreno, 2006).…”

International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors

“…In addition, BLT 1 expression is inducible in activated macrophages (Toda et al, 1999) and eosinophils treated with IL-5 (Huang et al, 1998), suggesting an association of BLT 1 with various inflammatory diseases. BLT 1 -transgenic mice showed enhanced PMN responses in the lung following ischemia-reperfusion and increased expression of 5-lipoxygenase in peritonitis (Chiang et al, 1999).…”

Tumor Necrosis Factor-α Generates Reactive Oxygen Species via a Cytosolic Phospholipase A2-linked Cascade

“…LTB 4 Interaction with BLTR Is Critical for TNF-␣ Signaling to ROS, JNK, and SRE-It has been suggested that LTB 4 acts in an autocrine manner via BLTR, its cell surface receptor (23)(24). We therefore examined the effect of ZK-158252 (Schering AG), a specific BLTR antagonist, on TNF-␣-induced ROS generation.…”