Cloning and Characterization of IL-10-Related T Cell-Derived Inducible Factor (IL-TIF), a Novel Cytokine Structurally Related to IL-10 and Inducible by IL-9

Dumoutier, Laure; Louahed, Jamila; Renauld, Jean‐Christophe

doi:10.4049/jimmunol.164.4.1814

Cited by 446 publications

(348 citation statements)

References 21 publications

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“…IL-22 was originally identified as a gene induced by IL-9 in murine T lymphocytes. Stimulation of HepG2 human hepatoma cells with IL-22 up-regulated the production of acute phase reactants like serum amyloid A, ␣ 1 -antichymotrypsin, and haptoglobin (11,12). Expression of MDA-7 was up-regulated in wound healing and during the in vitro differentiation of a melanoma cell line (13,14).…”

Section: Il-19 Induces Production Of Il-6 and Tnf-␣ And Results Inmentioning

confidence: 99%

IL-19 Induces Production of IL-6 and TNF-α and Results in Cell Apoptosis Through TNF-α

Liao

Liang

Chen

et al. 2002

The Journal of Immunology

308

235

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IL-10 is an immunosuppressive cytokine in the immune system. It was in clinical trail as an anti-inflammatory therapy for inflammatory bowel disease and various autoimmune diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis. IL-19 belongs to the IL-10 family, which includes IL-10, IL-19, IL-20, IL-22, melanoma differentiation-associated gene (MDA-7, IL-24), and AK155 (IL-26). Despite a partial homology in their amino acid sequences, they are dissimilar in their biologic functions. Little is known about the biologic function and gene regulation of IL-19. To understand the gene regulation of human IL-19, we identified a human IL-19 genomic clone and analyzed its promoter region. Five fusion genes containing different regions upstream of exon 1 linked to a luciferase reporter gene were expressed in the canine kidney epithelial-like Madin-Darby canine kidney cells. A fusion gene containing 394 bp showed luciferase activity 7- to 8-fold higher than the negative control of the promoterless fusion gene. We also isolated a full-length mouse cDNA clone. Mouse IL-19 shared 71% amino acid identity with human IL-19. Treatment of monocytes with mouse IL-19 induced the production of IL-6 and TNF-α. It also induced mouse monocyte apoptosis and the production of reactive oxygen species. Taken together, our results indicate that mouse IL-19 may play some important roles in inflammatory responses because it up-regulates IL-6 and TNF-α and induces apoptosis.

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Section: Il-19 Induces Production Of Il-6 and Tnf-␣ And Results Inmentioning

confidence: 99%

IL-19 Induces Production of IL-6 and TNF-α and Results in Cell Apoptosis Through TNF-α

Liao

Liang

Chen

et al. 2002

The Journal of Immunology

308

235

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“…In systemic diseases, it appears that IL-22 is primarily produced by T cells, most commonly Th1 and Th17 cells, with less expression from NK cells [10,14]. Research in reproductive tissues is not as definitive, but a few studies have identified uNK cells that are capable of expressing IL-22 [15].…”

Section: Introductionmentioning

confidence: 99%

Expression of interleukin-22 in decidua of patients with early pregnancy and unexplained recurrent pregnancy loss

Perfetto

Fan

Dahl

et al. 2015

J Assist Reprod Genet

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Purpose Researchers have hypothesized that an imbalance of immune cells in the uterine decidua and a dysfunction in cytokines they produce may contribute to recurrent pregnancy loss (RPL). The objective of this study was to determine if IL-22, IL-23 and IL-17 are expressed abnormally in the decidua of patients with RPL compared to those women with a normal pregnancy. We also sought to confirm that uterine natural killer (uNK) cells are lower in the decidua of patients with RPL, as well as identify IL-22 expression by uNK cells. Methods After meeting strict inclusion criteria, maternal decidua of nine patients with unexplained RPL and a confirmed euploid fetal loss, and 11 gestational age-matched patients undergoing elective pregnancy termination were included in our analysis. Quantitative real time-polymerase chain reaction (qRT-PCR) was performed to quantify RNA expression, Western blot was performed to quantify protein expression and immunohistochemistry (IHC) was performed to identify IL-22 and uNK cells. Results We found that women with unexplained RPL and a euploid fetal loss had significantly less gene and protein expression of IL-22 in the decidua. Additionally, we found that IL-22 is primarily expressed by uNK cells in the decidua. Conclusions In conclusion, our results suggest that lower levels of IL-22 in the uterine decidua in patients with unexplained RPL may contribute to a disruption of decidual homeostasis and ultimately lead to early pregnancy loss.

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“…IFN-γ, a classical Th1 cell cytokine, is secreted by the CD4 + Th1 cells but also produced by CD8 + cytotoxic lymphocytes, natural killer cells (Young 1996), and professional antigen-presenting cells (Frucht et al 2001;Harris et al 2000). IL-22 is produced primarily by a subtype of CD4 + T cells, now known as Th17 cells (Dumoutier et al 2000a) while IL-26 mainly by various types of T cells (CD4, CD8, αβ, γδ; Knappe et al 2000). Many aspects of IFN-γ have been elucidated, including the important roles as a potent activator of macrophages and the key regulators in cell-mediated immunity (Schroder et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Comparative study and expression analysis of the interferon gamma gene locus cytokines in Xenopus tropicalis

Nie

2008

Immunogenetics

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Using bioinformatics approach, the genome locus containing interleukin (IL)-22, IL-26, and interferon gamma (IFN-γ) genes has been identified in the amphibian, Xenopus tropicalis. Like that in other vertebrates such as fish, birds, and mammals, the Xenopus IL-22, IL-26, and IFN-γ are clustered in the same chromosome and the adjacent genes are conserved. The genomic structures of the Xenopus IL-22, IL-26, and IFN-γ gene were identical to that of their mammalian counterparts. The Xenopus IL-22 and IL-26 genes contained five exons and four introns while the Xenopus IFN-γ gene consisted of four exons and three introns. The Xenopus IL-22, IL-26, and IFN-γ share 14.1-41.6%, 14.6-31.2%, and 23.7-36.5% identity to their counterparts in other species, respectively. Reversetranscription polymerase chain reaction (PCR) and realtime quantitative PCR analyses revealed that the expression of IL-22, IL-26, and IFN-γ genes was significantly upregulated after simulation with bacterial polyliposaccharide and/or synthetic double-stranded poly(I:C), suggesting these cytokines like those in other vertebrates play an important role in regulating immune response in Xenopus.

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Cloning and Characterization of IL-10-Related T Cell-Derived Inducible Factor (IL-TIF), a Novel Cytokine Structurally Related to IL-10 and Inducible by IL-9

Cited by 446 publications

References 21 publications

IL-19 Induces Production of IL-6 and TNF-α and Results in Cell Apoptosis Through TNF-α

IL-19 Induces Production of IL-6 and TNF-α and Results in Cell Apoptosis Through TNF-α

Expression of interleukin-22 in decidua of patients with early pregnancy and unexplained recurrent pregnancy loss

Comparative study and expression analysis of the interferon gamma gene locus cytokines in Xenopus tropicalis

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