Clonidine prolongs the effect of ropivacaine for axillary brachial plexus blockade

Saied, A. H. El; Steyn, M. P.; Ansermino, J. Mark

doi:10.1007/bf03024866

Cited by 110 publications

(98 citation statements)

References 25 publications

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“…In group 2, it showed significant reduction both intraoperatively and postoperatively as compared to baseline values, but no active clinical intervention is required. These findings are in line with the works of El Saied et al 24 who found no significant changes in blood pressure when 150 mcg of clonidine was added to ropivacaine.…”

Section: Discussionsupporting

confidence: 92%

A Comparitive Evaluation of 0.75% Ropivacaine With Clonidine and 0.75% Ropivacaine With Dexmedetomidine in Supraclavicular Brachial Plexus Block- A Prospective Randomised Double-Blind Study

Balasubramanyam¹,

N²,

Jamuna³

2018

jebmh

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Section: Discussionsupporting

confidence: 92%

A Comparitive Evaluation of 0.75% Ropivacaine With Clonidine and 0.75% Ropivacaine With Dexmedetomidine in Supraclavicular Brachial Plexus Block- A Prospective Randomised Double-Blind Study

Balasubramanyam¹,

N²,

Jamuna³

2018

jebmh

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“…(11,12) Results were presented as mean ± standard deviation for parametric data and as percentages for nonparametric data. A p-value of < 0.05 was considered statistically significant and a p-value of < 0.001 was taken to be highly significant.…”

Section: Resultsmentioning

confidence: 99%

Addition of clonidine or lignocaine to ropivacaine for supraclavicular brachial plexus block: a comparative study

Rohan¹,

Singh²,

Khurana³

2014

smedj

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“…Similar results were obtained by El Saied et al They found no significant difference in sensory and motor block onset time in each individual group (p>0.05). 9 The mean duration of sensory and motor block was significantly prolonged (p<0.001) by addition of clonidine to ropivacaine. These results are in consistent with the earlier studies.…”

Section: Discussionmentioning

confidence: 94%

A double blind randomized study to assess the addition of clonidine to ropivacaine in supraclavicular brachial plexus block

2016

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INTRODUCTIONBlocking of supraclavicular brachial plexus during upper limb surgeries was found to be very effective in producing anaesthesia and analgesia. This type of peripheral nerve blocks provide intraoperative and postoperative analgesia without any systemic sideeffects.1 Ropivacaineis an amide, local anaesthetic agent, eliciting nerve block via reversible inhibition of sodium influx in nerve fibres. A clinically adequate dose of ropivacaine with its efficacy, lower propensity for motor block and reduced potential for CNS and cardiac toxicity than bupivacaine, appears to be an important option for regional anaesthesia for upper limb surgeries.2 Concurrent administration of adjuvants like clonidine to local anaesthetics in brachial plexus block may enhance the quality and duration of analgesia. The purpose of our study was to determine the efficacy of clonidine as an adjuvant to ropivacaine for supraclavicular brachial plexus block in terms of onset, duration, degree of sensory and motor blockade, postoperative analgesia and any complications if produced. ABSTRACT Background:The supraclavicular brachial plexus block provides anesthesia of the entire upper extremity in consistent and time-efficient manner. Ropivacaine is an amide, local anaesthetic agent, eliciting nerve block in brachial plexus. Clonidine as an adjuvant to ropivacaine enhances the quality and duration of analgesia when given epidurally or intrathecally. The aim of the present study was to assess the effect of adding clonidine to ropivacaine in supraclavicular brachial plexus block. Methods: Sixty patients were randomly divided into two groups, Group C and R. Group C received 0.5% of ropivacaine with 1 ml normal saline while Group R received same amount of ropivacaine with 1 ml (equivalent to 100μg) of clonidine for supraclavicular brachial plexus block. The groups were compared regarding quality of sensory and motor blockade, duration of post-operative analgesia, intra and post-operative hemodynamic changes and sedation scores. Results: There was a significant increase in duration of sensory and motor block and duration of analgesia in Group C as compared to Group R (P<0.001). There was no significant difference in mean onset time for sensory and motor blockade, the hemodynamic parameters (pulse rate, diastolic and systolic blood pressure)during and after surgery, sedation score post operatively in either groups (P>0.05). Conclusions: Clonidine 100µg added to 0.5% ropivacaine for supraclavicular brachial plexus block, does not shorten the onset of sensory and motor blockade but the combination produced prolonged sensory and motor blockade, improved and prolonged duration of analgesia, thereby decreasing the need for systemic analgesics without any hemodynamic changes.

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Clonidine prolongs the effect of ropivacaine for axillary brachial plexus blockade

Cited by 110 publications

References 25 publications

A Comparitive Evaluation of 0.75% Ropivacaine With Clonidine and 0.75% Ropivacaine With Dexmedetomidine in Supraclavicular Brachial Plexus Block- A Prospective Randomised Double-Blind Study

A Comparitive Evaluation of 0.75% Ropivacaine With Clonidine and 0.75% Ropivacaine With Dexmedetomidine in Supraclavicular Brachial Plexus Block- A Prospective Randomised Double-Blind Study

Addition of clonidine or lignocaine to ropivacaine for supraclavicular brachial plexus block: a comparative study

A double blind randomized study to assess the addition of clonidine to ropivacaine in supraclavicular brachial plexus block

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