Clonidine Pretreatment Inhibits Stress-Induced Gastric Ulcer in Rats

Yelken, Birgül; Dorman, Todd; Erkasap, Serdar; Dündar, Emine; Tanriverdi, Belkıs

doi:10.1097/00000539-199907000-00028

Cited by 14 publications

(6 citation statements)

References 23 publications

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“…The high ulcer indices in rats treated with these ulcerogens in this study confirm the efficacy of these methods and the veracity of these reports. Involvement of oxygen‐derived free radicals in the pathogenesis of gastrointestinal mucosal damage induced by NSAIDs [23], ethanol [24–26], feeding restriction stress [27], and H. pylori [28,29] is well established. It has also been suggested that free radicals generated by neutrophils may be an important factor delaying the healing of acetic acid‐induced chronic gastric ulcer injury [16].…”

Section: Discussionmentioning

confidence: 99%

Comparative gastroprotective effect of post‐treatment with low doses of rutin and cimetidine in rats

Olaleye¹,

Akinmoladun²

2011

Fundamemntal Clinical Pharma

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The anti-ulcerogenic potentials of low doses of rutin and cimetidine in ethanol-, acetic acid-, and stress-induced ulcers in rats have been evaluated and compared in this study. In each model, male Wistar rats were randomly divided into six groups (I-VI). Groups II-VI were administered 1 mL/100 g ethanol orally, 0.05 mL of 20% acetic acid submucosally or kept in a cold chamber for 6 h to induce ulcer in the ethanol-, acetic acid-, and stress-induced ulceration model, respectively. Thereafter, group III was post-treated with 300 mg/kg cimetidine and groups IV-VI with 20, 40, and 80 mg/kg rutin, respectively, while the control (group I) received distilled water in Tween 20. One hour after post-treatment, all groups were killed and the gastric ulcer index was calculated. Malondialdehyde (MDA) level, vitamin C content, and glutathione peroxidase (GPx) activity were evaluated in the gastric mucosa of animals. Post-treatment with rutin significantly reduced ulcerogen-induced gastric damage in all models. This effect was significant at all dose levels compared with the ulcer-induced groups. Rutin significantly reduced the MDA levels but increased the vitamin C content and GPx activity. Ulcer index and MDA level were highest in the ethanol-induced ulcer model while vitamin C content and GPx activity were lowest in the stress-induced ulcer model. The study showed that all three models of ulceration appeared to be linked to oxidative stress and also ascribed significant anti-ulcerogenic potential to rutin especially at lower doses of 20-80 mg/kg.

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Section: Discussionmentioning

confidence: 99%

Comparative gastroprotective effect of post‐treatment with low doses of rutin and cimetidine in rats

Olaleye¹,

Akinmoladun²

2011

Fundamemntal Clinical Pharma

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“…Central sympathetic activation was examined with the use of clonidine, a commonly applied pharmacological model; after an initial peripheral α 1 -stimulation, the central action of clonidine prevails, resulting in inhibition of sympathetic preganglionic neurons and decreased sympathetic drive ( 21 ). As previously ( 22 ), clonidine was given intraperitoneally (0.5 mg/kg), 1 h prior to the experiments.…”

Section: Methodsmentioning

confidence: 99%

Central Sympathetic Activation and Arrhythmogenesis during Acute Myocardial Infarction: Modulating Effects of Endothelin-B Receptors

Kolettis

Kontonika

Barka

et al. 2015

Front. Cardiovasc. Med.

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Sympathetic activation during acute myocardial infarction (MI) is an important arrhythmogenic mechanism, but the role of central autonomic inputs and their modulating factors remain unclear. Using the in vivo rat-model, we examined the effects of clonidine, a centrally acting sympatholytic agent, in the presence or absence of myocardial endothelin-B (ETB) receptors. We studied wild-type (n = 20) and ETB-deficient rats (n = 20) after permanent coronary ligation, with or without pretreatment with clonidine. Cardiac rhythm was continuously recorded for 24 h by implantable telemetry devices, coupled by the assessment of autonomic and heart failure indices. Sympathetic activation and arrhythmogenesis were more prominent in ETB-deficient rats during the early phase post-ligation. Clonidine improved these outcomes throughout the observation period in ETB-deficient rats, but only during the delayed phase in wild-type rats. However, this benefit was counterbalanced by atrioventricular conduction abnormalities and by higher incidence of heart failure, the latter particularly evident in ETB-deficient rats. Myocardial ETB-receptors attenuate the arrhythmogenic effects of central sympathetic activation during acute MI. ETB-receptor deficiency potentiates the sympatholytic effects of clonidine and aggravates heart failure. The interaction between endothelin and sympathetic responses during myocardial ischemia/infarction and its impact on arrhythmogenesis and left ventricular dysfunction merits further investigation.

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“…The α 2-noradrenergic receptors and the α 2 presynaptic are involved in the regulation of gastric acid secretion and are effective in protection against chemical agents such as NSAIDs and ethanol, where their effects may be mediated central and peripheral receptors [47]. …”

Section: Discussionmentioning

confidence: 99%

Antiulcerogenic Activity of the Hydroalcoholic Extract of Leaves ofCroton campestrisA. St.-Hill in Rodents

Júnior

Oliveira

Bento

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Croton campestris A. St.-Hill., popularly known as “velame do campo,” is a species native to the savannah area of Northeast Brazil, which is used by traditional communities in folk medicine for variety of health problems, especially detoxification, inflammation, and gastritis. The hydroalcoholic extract of C. campestris leaves (HELCC) was assessed for its antiulcerogenic effect in gastric lesion models and effect on intestinal motility in mice, and possible mechanisms of action were examined. HELCC showed significant gastroprotective action in all models of gastric ulcer evaluated; the results suggest that this action probably involves the nitric oxide pathway. HELCC did not show alteration of intestinal motility in mice. It was also found that C. campestris represents a promising natural source with important biological potential, justifying some of its uses in folk medicine.

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Clonidine Pretreatment Inhibits Stress-Induced Gastric Ulcer in Rats

Abstract: Stressful circumstances can cause stomach ulcers, which can bleed, exposing patients to potentially life-threatening complications. In the present animal study, we showed that clonidine, a routinely available medication, may be useful in preventing stress-induced stomach ulcers.

Cited by 14 publications

References 23 publications

Comparative gastroprotective effect of post‐treatment with low doses of rutin and cimetidine in rats

Comparative gastroprotective effect of post‐treatment with low doses of rutin and cimetidine in rats

Central Sympathetic Activation and Arrhythmogenesis during Acute Myocardial Infarction: Modulating Effects of Endothelin-B Receptors

Antiulcerogenic Activity of the Hydroalcoholic Extract of Leaves ofCroton campestrisA. St.-Hill in Rodents

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