Clonidine in Thousand-Fold Overdose

Toxic clonidine ingestion in children

“…Similar favorable outcomes with supportive therapy have occurred in adults with inadvertent 1000-fold overdoses. 17 Finally, in our case series, all clinical effects were evident rapidly after ingestion, with a mean of 1.7 hours. This is consistent with the findings of Wiley et al 12 in a case series of 47 patients.…”

Topics in Clinical Pharmacology and Therapeutics

“…The major findings are: The above symptoms occurred in a 17-year-old girl who had ingested 11.25 mg clonidine (285) and in a 44-year-old woman who inadvertently ingested 25 mg clonidine (298). With high serum concentrations, the central inhibitory effect of clonidine on blood pressure may be lost, and severe hypertension may result from the drug's peripheral action.…”