Clonidine in paediatric anaesthesia

Nishina, Kahoru; Mikawa, Katsuya; Shiga, Motoyuki; Obara, Hidefumi

doi:10.1046/j.1460-9592.1999.00379.x

Cited by 113 publications

(92 citation statements)

References 130 publications

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“…Clonidine has few clinically significant respiratory depressant effects when used at doses of 3 to 4 μ g/kg [14, 16, 39–46]. In otherwise healthy adults declines in oxygen saturation were ≤1% following oral clonidine [15].…”

Section: Discussionmentioning

confidence: 99%

“…Clonidine is a central alpha 2 -adrenergic receptor agonist used as a provocative agent to assess growth hormone (GH) secretion but also has analgesic and sedative properties and is used as a preanesthetic medication in adults and children [14]. Unlike most sedatives clonidine has minimal clinically significant respiratory depressant effects (decrease in oxygen saturation of ≤1%) in healthy adults when used at oral doses of 3 to 4 μ g/kg [15].…”

Section: Introductionmentioning

confidence: 99%

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Respiratory Depression in Young Prader Willi Syndrome Patients following Clonidine Provocation for Growth Hormone Secretion Testing

Hollman

Allen

Eickhoff

et al. 2010

International Journal of Pediatric Endocrinology

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Objectives. To determine the sedative and respiratory effects of clonidine when used to evaluate growth hormone (GH) secretion in children with Prader Willi Syndrome (PWS). Methods. The study prospectively evaluated children with PWS who received clonidine (0.15 mg/m2) to assess GH responsiveness. Patients were studied up to four times over three years. Vital signs, oxygen saturation, and sedation level were recorded at baseline and every five minutes following clonidine. Changes between baseline and post-clonidine were evaluated using a repeated measurement analysis. Results. Sixty studies were performed on 17 patients, mean age 30.4 ± 15.0 months. The mean ± SD dose of clonidine was 0.074 ± 0.027 mg (5.3 ± 1.72 mcg/kg). All patients achieved a sedation score of 4 to 5 (drowsy to asleep). Mean declines in respiratory rate (7.5 ± 6.1 breaths/min; P < .001), and oxygen saturation (2.2 ± 2.0%; P < .001) occurred following clonidine. Five patients (29%) experienced oxygen saturations ≤94% on nine occasions. Three oxygen desaturations were accompanied by partial airway obstruction. Conclusions. Clonidine doses to assess GH secretion often exceed doses used for sedation and result in significant respiratory depression in some children with PWS. There was no association between oxygen desaturation and BMI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Respiratory Depression in Young Prader Willi Syndrome Patients following Clonidine Provocation for Growth Hormone Secretion Testing

Hollman

Allen

Eickhoff

et al. 2010

International Journal of Pediatric Endocrinology

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“…· Clonidina A clonidina é um agonista a 2 -adrenérgico com propriedades analgésicas, ansiolíticas e sedativas 68 . Aadministração de 4 µg.kg -1 por via oral promove sedação, diminui o consumo de anestésico no intra-operatório e de analgésicos no pós-operatório [68][69][70] .…”

Section: · Cetaminaunclassified

“…Aadministração de 4 µg.kg -1 por via oral promove sedação, diminui o consumo de anestésico no intra-operatório e de analgésicos no pós-operatório [68][69][70] . O pico da concentração plasmática é de 60 a 90 minutos, após o emprego pela via oral.…”

Section: · Cetaminaunclassified

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Ansiedade, a criança e os pais

Moro¹,

Módolo²

2004

Rev. Bras. Anestesiol.

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RESUMO C ON C L U S ÕE S : O p e r í o d o q u e a n t e c e d e a c i r u r g i a acompanha-se de grande carga emocional para toda família, sobretudo para a criança. Um pré-operatório turbulento significa, para muitas crianças, alterações de comportamento que se manifestam de forma variada e por períodos prolongados em algumas vezes. A presença dos pais durante a i n d u ç ã o d a a n e s t e s i a e p r o g r a m a s d e p r e p a r a ç ã o pré-operatórios para a criança e para os pais U n i t e r m o s : A N E S T E S I A , P e d i á t r i c a ; AVA L I A Ç Ã O

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