Clonidine Combined with Small-Dose Bupivacaine During Spinal Anesthesia for Inguinal Herniorrhaphy: A Randomized Double-Blinded Study

Dobrydnjov, Igor; Axelsson, Kjell; Thörn, Sven‐Egron; Matthiesen, P.; Klockhoff, H.; Holmström, Björn; Gupta, Amrita

doi:10.1213/01.ane.0000061110.62841.e9

Cited by 100 publications

(136 citation statements)

References 22 publications

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“…19 The data match with our results concerning the duration of sensory block-postoperative analgesia. Our results showed that the addition of a small dose (25 µg) of clonidine increased the spread (onset-T9) and duration of sensory block, thereby prolonging postoperative analgesia.…”

Section: Discussionsupporting

confidence: 90%

Intrathecal clonidine added to small-dose bupivacaine prolongs

Gecaj-Gashi

Terziqi

Pervorfi

et al. 2013

CUAJ

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Introduction: The aim of this prospective, double-blinded study was to investigate the effects of clonidine in co-administration with bupivacaine during spinal anesthesia, regarding the onset and regression of motor and sensory block, postoperative analgesia and possible side effects. Methods: We randomly selected 66 male patients (age 35 to 70), from the American Society of Anesthesiologists (ASA) class I-II; these patients were scheduled for transurethral surgical procedures. These patients were randomly allocated into two groups of 33 patients each: group B (bupivacaine) only received 0.5% isobaric bupivacaine 7.5 mg intrathecally and group BC (bupivacaine + clonidine) received bupivacaine 7.5 mg and clonidine 25 µg intrathecally. We performed the spinal anesthesia at a level of L3-L4 with a 25-gauge needle. We assessed the sensory block with a pinprick, the motor block using the Bromage scale, analgesia with the visual analog scale and sedation with the modified Wilson scale. We also recorded the hemodynamic and respiratory parameters. Results: The groups were demographically similar. The mean time of achievement of motor block (Bromage 3) and sensory block at level T9 was significantly shorter in the BC group compared with B group (p = 0.002, p = 0.000, respeectively). The motor block regression time was not significantly different between the two groups (p = 0.237). The postoperative analgesia requirement was significantly longer in group BC compared with group B (p = 0.000). No neurological deficit, sedation or other significant adverse effects were recorded. Conclusion: The intrathecal application of clonidine in combination with bupivacaine improves the duration and quality of spinal anesthesia; it also provides longer duration of postoperative analgesia, without significant side effects.

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Section: Discussionsupporting

confidence: 90%

Intrathecal clonidine added to small-dose bupivacaine prolongs

Gecaj-Gashi

Terziqi

Pervorfi

et al. 2013

CUAJ

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“…According to some previous studies, intrathecal clonidine alone, even at doses above 450 µg, does not cause muscular weakness and motor blockade, 16 but combined with local anesthetics it significantly enhances the intensity and duration of motor blockade. 17,18 In our study, however, we found a significant difference in the TAMB between the two groups, in favour of the clonidine group, but we failed to achieve statistical significance in the duration of the motor block. The higher doses of clonidine have been reported to cause important decreases in arterial pressure and marked sedation.…”

Section: Discussioncontrasting

confidence: 79%

Effect of Clonidine and/or Fentanyl in Combination with Intrathecal Bupivacaine for Lower Limb Orthopedic Surgeries in Spinal Anaesthesia

Hakim¹

2017

jmscr

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“…The mean time to two-segment regression, regression to L3 dermatome and time to first rescue analgesic request was significantly more in clonidine group than butorphanol group. Our findings were similar to study conducted by Van Tuijl et al [13,14] and Dobrydnjov et al [15] suggesting that the dose of intrathecal clonidine does not affect the mean maximal level of sensory block.…”

Section: Discussionsupporting

confidence: 93%

Clonidine versus butorphanol as adjuvant to 0.5% hyperbaric bupivacaine to enhance the onset and duration of subarachnoid blockade with postoperative analgesia during orthopaedic surgeries-A randomized study

2015

Glob Anaesth Perioper Med

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Clonidine Combined with Small-Dose Bupivacaine During Spinal Anesthesia for Inguinal Herniorrhaphy: A Randomized Double-Blinded Study

Abstract: The addition of clonidine 15 micro g to 6 mg of hyperbaric bupivacaine increases the spread of analgesia, prolongs the time to first analgesic request, and decreases postoperative pain, compared with bupivacaine alone, during inguinal herniorrhaphy under spinal anesthesia.

Cited by 100 publications

References 22 publications

Intrathecal clonidine added to small-dose bupivacaine prolongs

Intrathecal clonidine added to small-dose bupivacaine prolongs

Effect of Clonidine and/or Fentanyl in Combination with Intrathecal Bupivacaine for Lower Limb Orthopedic Surgeries in Spinal Anaesthesia

Clonidine versus butorphanol as adjuvant to 0.5% hyperbaric bupivacaine to enhance the onset and duration of subarachnoid blockade with postoperative analgesia during orthopaedic surgeries-A randomized study

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