Clonidine changes lidocaine free concentrations in rat myocardium without affecting heart function measured by echocardiography

Tigka, E.; Kotsiou, Antonia; Saranteas, Theodosios; Mourouzis, J; Kostopanagiotou, Georgia; Tesseromatis, C.

doi:10.1007/bf03191178

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…A decrease in the effective analgesic dose of lidocaine could be achieved, avoiding any undesirable effects on the cardiovascular system. An ultrasound study of the heart has recently proved that there are no statistically significant pharmacodynamic alterations when clonidine is co-administered with lidocaine, in terms of heart function parameters (18).…”

Section: Discussionmentioning

confidence: 99%

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The influence of clonidine co-administration on the extent of lidocaine protein binding to rat serum and tissues

et al. 2011

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Lidocaine is an amide local anesthetic and clonidine is an antihypertensive (α2-adrenergic agonist).The use of these two drugs in combination is recommended to enhance the analgesic effect of lidocaine. The aim of this study was to investigate the influence of clonidine co-administration on the extent of lidocaine binding to rat serum, heart and maxillofacial tissues in vivo and in vitro. Thirty-two Wistar rats received either lidocaine alone, or lidocaine and clonidine, in the masseter muscle, and were then sacrificed 15 or 30 min after treatment. Serum, masseter, mandible and heart samples were then isolated and incubated in 0.9% NaCl solution for 12 h at 8°C. The extent of binding in the incubation medium and the serum was estimated by ultrafiltration, and the free lidocaine fraction was determined by the radioscopic method in a β-counter. An in vitro procedure was also performed. Serum, heart, masseter and mandible samples were incubated at 37°C for 15 or 30 min in Ringer's solution containing either lidocaine or lidocaine and clonidine, and the samples were similarly subjected to ultrafiltration. The percentage binding of lidocaine was again estimated by the radioscopic method. Lidocaine levels were found to be increased by clonidine co-administration in vivo and the free lidocaine fraction was enhanced in vitro as well in the examined tissues, obviously through mechanisms related to protein binding alterations. (J Oral Sci 53, 61-66, 2011)

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Section: Discussionmentioning

confidence: 99%

“…A previous study has indicated that clonidine administration influences the extent of lidocaine binding and enhances free lidocaine in rat serum and heart tissue protein (18).…”

Section: Introductionmentioning

confidence: 98%

The influence of clonidine co-administration on the extent of lidocaine protein binding to rat serum and tissues

et al. 2011

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“…Probably a displacement process takes place and lidocaine is displaced by clonidine from its binding sites in serum and tissue proteins thereby leading to rise in its free fraction. [59]. Drugs that are documented to be of AAP depended activity are presented in the following table (1)…”

Section: Aag Binding Experimental Studiesmentioning

confidence: 99%