Clonidine and Haloperidol in Gilles de la Tourette Syndrome-Reply

Cohen, Donald J.

doi:10.1001/archpsyc.1981.01780350118016

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…These include compulsions [Leckman et al 1982], hyperactivity and impulsivity [Leckman et al 1991]. Cohen and colleagues showed that 70% of patients showed a reduction in tics, and that additional improvement in frustration, aggression, obsessivecompulsive and oppositional behaviours were seen [Cohen et al 1981[Cohen et al , 1980. Sandyk reported the case of a 15-year-old boy with TS and severe self-mutilatory behaviour [Sandyk, 1986].…”

Section: Noradrenaline Modulating Agentsmentioning

confidence: 99%

Treatment strategies for tics in Tourette syndrome

Eddy

Rickards

Cavanna

2010

Ther Adv Neurol Disord

144

114

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Tourette syndrome (TS) is a chronic neurodevelopmental disorder characterized by tics: repetitive, involuntary movements and vocalizations. These symptoms can have a significant impact on patients' daily functioning across many domains. Tics tend to be most severe in child and adolescent sufferers, so their presence has the potential to impact a period of life that is both critical for learning and is often associated with the experience of greater social tension and self-consciousness than adulthood. Furthermore, control over tics that lead to physical impairment or self-injurious behaviour is of vital importance in maintaining health and quality of life. There are numerous complicating factors in the prescription of treatment for tics, due to both the side effects associated with alleviating agents and patient characteristics, such as age and comorbid conditions. This review summarizes literature pertaining to the efficacy and safety of both traditionally prescribed and more modern medications. We also discuss the merits of behavioural and surgical techniques and highlight newer emerging treatments. Although treatment response is to some extent variable, there are a number of agents that are clearly useful as first-line treatments for TS. Other interventions may be of most benefit to patients exhibiting refractory tics or more specific symptom profiles.

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Section: Noradrenaline Modulating Agentsmentioning

confidence: 99%

Treatment strategies for tics in Tourette syndrome

Eddy

Rickards

Cavanna

2010

Ther Adv Neurol Disord

144

114

View full text Add to dashboard Cite

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“…Contrary to previous beliefs, exacerbation of tics with psychostimulants is not an inevitable outcome. Hence, aggressive treatment of comorbid ADHD in TS is recommended [ 10 ]. In R., addition of MPH had the desired effect of improving ADHD symptoms with no exacerbation of tics, despite severe symptoms at the beginning.…”

Section: Discussionmentioning

confidence: 99%

Management of Severe Pediatric Tourette Syndrome Resistant to Drug Treatment

Perera

Abayanayaka

2012

Case Reports in Psychiatry

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Tourette syndrome (TS) is a neurodevelopmental disorder with chronic and disabling impacts on multiple domains of functioning in children. Treatment of TS is often complicated by comorbid conditions. We present a 12-year-old boy with severe symptoms of Tourette syndrome (TS), with prominent and markedly disabling vocal tics, who failed to respond to substantial doses of risperidone and haloperidol, given for a prolonged period. Satisfactory outcome was achieved with exposure and response prevention, adjunct to medication. Comorbid ADHD was treated with stimulants with no exacerbation of tics.

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Treatment of Gilles de la Tourette's Syndrome With Clonidine and Neuroleptics

Shapiro¹

1983

Arch Gen Psychiatry

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Clonidine and Haloperidol in Gilles de la Tourette Syndrome-Reply

Cited by 6 publications

References 7 publications

Treatment strategies for tics in Tourette syndrome

Treatment strategies for tics in Tourette syndrome

Management of Severe Pediatric Tourette Syndrome Resistant to Drug Treatment

Treatment of Gilles de la Tourette's Syndrome With Clonidine and Neuroleptics

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