Clonidine addition prolongs the duration of caudal analgesia

Abstract

The addition of clonidine to 0.125% bupivacaine prolongs the duration of post-operative analgesia without any respiratory or haemodynamic side-effects.

Caudal Neostigmine and Clonidine as Adjuncts to Bupivacaine for Post Operative Analgesia in Children Undergoing Sub Umbilical Surgery

“…18 Yildiz T.S (2006) et al also observed that children undergoing elective inguinal repair receiving caudal clonidine -bupivacaine combination had increased duration of post operative analgesia without any respiratory and hemodynamic side effects. 19 The total number of patients who required rescue analgesia (diclofenac suppository) in postoperative period were less from study group as compared to control group and the difference was statistically significant (p<0.05). Comparison showed that adding clonidine with bupivacaine decreased the overall requirement of rescue analgesia postoperatively.…”

Addition of Clonidine in Caudal Anesthesia in Children Increases Duration of Post-Operative Analgesia

“…When analyzing the results, it was revealed that caudal clonidine with the dosage of 2 µg/kg resulted in longer analgesia when compared with dosage of 1 and 1.5 µg/kg. Additionally, it caused no hypotension or bradycardia peri-operatively and no respiratory depression or loss of motion postoperatively (10).…”

Caudal Additives Do Not Improve the Analgesia Afforded by Levobupivacaine After Hypospadias Repair

“…Poxstoperative analgesia may be prolonged by a continuous infusion of local anesthetic or, potentially, by using additives. In the European Union, S (+)-ketamine and clonidine are now widely used as caudal additives, and evidence to support their use is available (4)(5)(6)(7)(8)(9)(10)(11)(12), particularly when used with racemic bupivacaine (4, 5, 7-10).…”