1992
DOI: 10.3109/10428199209053566
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Clone Emergence and Evolution in Chronic Lymphocytic Leukemia: Characterization of Clinical, Laboratory and Immunophenotypic Profiles of 25 Patients

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Cited by 15 publications
(9 citation statements)
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“…This finding is similar to an earlier study of patients with mild lymphocytosis, eight out of 24 of whom progressed to CLL in 5 years [45]. The Leeds group defined MBL as an absolute B-cell count of less than 5.0 × 10 9 /l with no lymphadenopathy and less than 30% CLL cells in the bone marrow if assessed [42].…”
Section: Monoclonal B-cell Lymphocytosis: Precursor Condition?supporting
confidence: 88%
“…This finding is similar to an earlier study of patients with mild lymphocytosis, eight out of 24 of whom progressed to CLL in 5 years [45]. The Leeds group defined MBL as an absolute B-cell count of less than 5.0 × 10 9 /l with no lymphadenopathy and less than 30% CLL cells in the bone marrow if assessed [42].…”
Section: Monoclonal B-cell Lymphocytosis: Precursor Condition?supporting
confidence: 88%
“…This is in keeping with the finding that a large proportion of patients with early stage CLL show stable disease and, occasionally, decreasing CLL cell counts (Table I). Faguet et al (1992) reported a series of 39 patients with a slight increase in their absolute lymphocyte count; 24 had an abnormal B-cell clone and eight of the 24 patients progressed to clinical B-cell CLL over 5 years. In the limited NCI follow-up of familial MBL, progression to CLL has not yet been observed.…”
Section: Natural History Of the Disordermentioning
confidence: 99%
“…However, the amount of data documenting the clinical course and outcome of MBL has not kept pace with the number of new diagnoses [6]. There is little information describing the clinical course of MBL, its prognostic factors or characteristics, and its relationship to CLL [10]. Here we present a retrospective study of 214 patients with clonal lymphoproliferation in keeping with CLL, 46 of whom presented with MBL.…”
Section: Introductionmentioning
confidence: 96%