Clonazolam a new designer benzodiazepine intoxication confirmed by blood concentration

Sommerfeld-Klatta, Karina; Łukasik-Głębocka, Magdalena; Tężyk, Artur; Panieński, Paweł; Żaba, Czesław; Zielińska-Psuja, Barbara

doi:10.1016/j.forsciint.2020.110237

Cited by 18 publications

(19 citation statements)

References 7 publications

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“…Data on blood or serum concentrations of designer benzodiazepines found in authentic samples is limited to a few compounds so far (clonazolam, diclazepam, flualprazolam, flubromazepam, flubromazolam, and pyrazolam) (Heide et al, 2020; Hoiseth et al, 2016; Huppertz et al, 2018; Kriikku et al, 2020; Moosmann et al, 2014; Moosmann, Huppertz, et al, 2013; Moosmann, Hutter, et al, 2013; Papsun, Krotulski, Homan, Temporal, & Logan, 2020; Rice, Hikin, Lawson, Smith, & Morley, 2020; Rohrig, Osawa, Baird, & Youso, 2020; Sommerfeld‐Klatta et al, 2020; Wagmann, Manier, Felske, et al, 2020).…”

Section: Methods Of Detectionmentioning

confidence: 99%

New psychoactive substances—Designer benzodiazepines

Wilde

Auwärter

Moosmann

2021

WIREs Forensic Science

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Designer benzodiazepines are a rather new class of new psychoactive substances counting 26 compounds by the end of 2019. However, due to their high habit‐forming potential, the easy availability of these drugs in online shops is rather alarming. While the risk of acute health effects or intoxications after the sole consumption of benzodiazepines is low, combined consumption with other central nervous system depressant drugs such as opioids or alcohol can lead to life‐threating conditions. Furthermore, long term use can lead to tolerance and addiction. In this review article the emergence of this drug class is described and the literature on pharmacokinetics and the various methods of detection is discussed. Furthermore, the structure activity relationships of benzodiazepines are summarized in order to predict the potency of newly emerging compounds. This article is categorized under: Toxicology > New Psychoactive Substances

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Section: Methods Of Detectionmentioning

confidence: 99%

New psychoactive substances—Designer benzodiazepines

Wilde

Auwärter

Moosmann

2021

WIREs Forensic Science

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“…To the aforementioned problems, we have to add that it is currently possible to find associated drugs known as "designed benzodiazepines" on the market, belonging to the new group of drugs called "new psychoactive substances" (NSP). These substances, which are obtained by modifying the basic BDZs (Figure 9), have not been approved as medicines, so they could be dangerous for the health of consumers [56,57]. As an example, in late 2017, the case of a girl who was stolen after drinking tea with a man she met via the Internet and who added flubromazolam in her drink was reported.…”

Section: Chemically Modified Benzodiazepinesmentioning

confidence: 99%

Benzodiazepines: Their Use either as Essential Medicines or as Toxics Substances

Sanabria

Cuenca

Esteso

et al. 2021

Toxics

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“…6 This diversity can be exemplified by the four different new psychoactive substances JWH-018, one of the first identified synthetic cannabinoids, 11 the hallucinogenic phenethylamine 25I-NBOMe, 12 the potent synthetic opioid acrylfentanyl and the anxiolytic benzodiazepine, clonazolam ( Figure 2). 13,14 Consequently, the pharmacological properties of NPS also vary widely. 15 It is therefore difficult to discuss the specific effects on human health from NPS abuse in terms of toxicity.…”

Section: Effects On Human Healthmentioning

confidence: 99%

An insight into the metabolism of New Psychoactive Substances : Structural elucidation of urinary metabolites of synthetic cannabinoids and fentanyl analogues using synthesized reference standards

Wallgren

2020

Linköping Studies in Science and Technology. Dissertations

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New Psychoactive Substances (NPS) is an umbrella term covering hundreds of substances across different drug groups. Many of these substances were originally developed for therapeutic use but have later appeared on the recreational drug market. The use of NPS has been associated with many outbreaks leading to hospitalizations and has been implicated in numerous fatalities worldwide. To be able to analytically detect drugs in a forensic setting is vital in the fight against the abuse of NPS. One of the most notable challenges in detection of NPS is the identification of major urinary metabolites for use as biomarkers. Furthermore, given the lack of reference standards in most metabolism studies, the major urinary metabolites can often only be tentatively determined. Docent Johan Dahlén, my main supervisor, for allowing me the opportunity to carry out my research as a PhD student. Thank you for your positive attitude, support, encouragement and for your ability to turn problems into opportunities. Professor Peter Konradsson, my co-supervisor, for accepting me as a PhD student and for encouraging me to strive forward. Thank you for your guidance in chemistry as well as for your enjoyable music and sports analogies. Doctor Xiongyu Wu, my co-supervisor, for being an exceptional person and a master chemist. Thank you for always being there for me when I needed support or advice, never making me feel like a nuisance. You will always have my utmost admiration and appreciation. The people currently or previously working at the National Board of Forensic Medicine, Svante, Martin, Henrik, Anna, Robert, Ariane and Shimpei for excellent collaboration. Thank you for letting me partake in your fascinating research, it was the highlight of my time as a PhD student. Katriann Arja, for being a truly genuine and caring friend as well as an excellent life coach. Thank you for being a beacon of positivity and for lifting the spirits of everyone around you. Lastly, for our running sessions and discussions about happiness, Aitäh! Linda Lantz, my big sister at work, for taking me under your wing and making me feel at home. Thank you for trying to teach me everything from how to speak to how to run. Very few things make me as happy as baking pastries and treating you to them. Marcus Bäck, my brother from another mother, for your perpetual support, encouragement and most enjoyable company. Few people can relate to or understand me on a personal level as well as you can. VI Mathias Elgland, my doppelganger, for sharing all my peculiar interests. I have thoroughly enjoyed all our time together, from listening to Ludde to throwing flat circular objects around and everything in between. Anders Rexander, my former brother in arms, for all the enjoyable banter and hard-fought duels in various racket sports. The lab was never the same without you. Caroline Eriksson, my dear friend, for helping me break out of my shell. Few people have had such a positive impact on me as a person as you have. Tobias Abrahamsson for being around since the beginning...

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Clonazolam a new designer benzodiazepine intoxication confirmed by blood concentration

Cited by 18 publications

References 7 publications

New psychoactive substances—Designer benzodiazepines

New psychoactive substances—Designer benzodiazepines

Benzodiazepines: Their Use either as Essential Medicines or as Toxics Substances

An insight into the metabolism of New Psychoactive Substances : Structural elucidation of urinary metabolites of synthetic cannabinoids and fentanyl analogues using synthesized reference standards

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