Clonal T Cells in the Blood of Patients With Systemic Sclerosis

Marie, I.; Cordel, N.; Lenormand, Bernard; Hellot, Marie‐France; Lévesque, H.; Courtois, H; Joly, P.

doi:10.1001/archderm.141.1.88

Cited by 19 publications

(15 citation statements)

References 8 publications

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“…Similar to the findings of Marie et al. , 7 we did not observe a correlation between the presence of circulating clonal T cells and extent of skin sclerosis or organ involvement. Thus, the detection of T‐cell clonality in SSc cannot be considered as a predictive factor for disease severity.…”

Section: Discussionsupporting

confidence: 91%

“…5 Moreover, two pilot studies evaluated the amount of clonal T-cell populations in the peripheral blood of patients with SSc and found that 46% and 34% of patients had clonal T cells, respectively. 6,7 However, again the number of patients analysed in these two studies was small. The present study was initiated to search for expanded clonal T-cell populations in both peripheral blood and skin of a large collection of patients with SSc.…”

mentioning

confidence: 92%

“…Clonally expanded T cells have been found in lesional skin of a small number of patients with SSc 5 . Moreover, two pilot studies evaluated the amount of clonal T‐cell populations in the peripheral blood of patients with SSc and found that 46% and 34% of patients had clonal T cells, respectively 6,7 . However, again the number of patients analysed in these two studies was small.…”

mentioning

confidence: 99%

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Clonal T-cell populations are frequent in the skin and blood of patients with systemic sclerosis

Kreuter¹,

Höxtermann²,

Tigges³

et al. 2009

British Journal of Dermatology

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 92%

mentioning

confidence: 99%

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Clonal T-cell populations are frequent in the skin and blood of patients with systemic sclerosis

Kreuter¹,

Höxtermann²,

Tigges³

et al. 2009

British Journal of Dermatology

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“…Interestingly, it has been shown that fetal CD3 + T cells from prior pregnancies could be detected in the blood and lesional skin of a significant proportion (>50%) of females with SSc, suggesting that, in certain cases, T‐cell microchimerism may be directly involved in the pathogenesis of SSc by initiating a graft‐versus‐host‐like response. Furthermore, clonal T‐cell populations have been identified in the blood and skin of patients with SSc …”

Section: Sclerodermamentioning

confidence: 99%

Guidelines on the use of extracorporeal photopheresis

Knobler

Berlin

Calzavara‐Pinton

et al. 2013

Acad Dermatol Venereol

183

206

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BackgroundAfter the first investigational study on the use of extracorporeal photopheresis for the treatment of cutaneous T-cell lymphoma was published in 1983 with its subsequent recognition by the FDA for its refractory forms, the technology has shown significant promise in the treatment of other severe and refractory conditions in a multi-disciplinary setting. Among the major studied conditions are graft versus host disease after allogeneic bone marrow transplantation, systemic sclerosis, solid organ transplant rejection and inflammatory bowel disease.Materials and methodsIn order to provide recognized expert practical guidelines for the use of this technology for all indications the European Dermatology Forum (EDF) proceeded to address these questions in the hands of the recognized experts within and outside the field of dermatology. This was done using the recognized and approved guidelines of EDF for this task.Results and conclusionThese guidelines provide at present the most comprehensive available expert recommendations for the use of extracorporeal photopheresis based on the available published literature and expert consensus opinion.

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“…Sakkas et al observed a high percentage of identical TCRb chains in dermal infiltrating T cells from SSc patients and suggested that T cells had undergone clonal expansion in the affected skin [13]. Marie et al detected increases in the monoclonal population of the T cell g chain in patients with limited cutaneous compared with diffuse cutaneous involvement [23]. CD8 þ T cells were shown to have a restricted TCR repertoire in the lungs of SSC patients [24].…”

Section: Discussionmentioning

confidence: 99%