Clonal Somatic Mutations in Chronic Lung Diseases Are Associated with Reduced Lung Function

Yun, Jeong H.; Khan, M. A. Wasay; Ghosh, Auyon; Hobbs, Brian D.; Castaldi, Peter J.; Hersh, Craig P.; Miller, Peter G.; Cool, Carlyne D.; Sciurba, Frank; Barwick, Lucas; Limper, Andrew H.; Flaherty, Kevin; Criner, Gerard J.; Brown, Kevin; Wise, Robert; Martinez, Fernando; Silverman, Edwin K.; DeMeo, Dawn; ,; Cho, Michael H.; Bick, Alexander G.

doi:10.1164/rccm.202303-0395oc

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…This phenomenon has been identified as a contributor to inflammation and, given the continuous exchange of TR-AMs by BMDMs, may significantly affect lung health and disease in the aged. CHIP contributes to the altered inflammatory response seen in chronic diseases related to inflammatory macrophage phenotypes, including cardiovascular disease [ 165 ], COPD, IPF [ 162 , 166 , 167 ] and atherosclerosis [ 168 ]. The findings indicate an augmented risk of both the incidence and severity of COPD in patients exhibiting CHIP, thereby emphasising the potential clinical implications.…”

Section: The Aged Macrophagementioning

confidence: 99%

The guardians of pulmonary harmony: alveolar macrophages orchestrating the symphony of lung inflammation and tissue homeostasis

Pervizaj-Oruqaj,

Ferrero,

Matt

et al. 2024

Eur Respir Rev

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Recent breakthroughs in single-cell sequencing, advancements in cellular and tissue imaging techniques, innovations in cell lineage tracing, and insights into the epigenome collectively illuminate the enigmatic landscape of alveolar macrophages in the lung under homeostasis and disease conditions. Our current knowledge reveals the cellular and functional diversity of alveolar macrophages within the respiratory system, emphasising their remarkable adaptability. By synthesising insights from classical cell and developmental biology studies, we provide a comprehensive perspective on alveolar macrophage functional plasticity. This includes an examination of their ontology-related features, their role in maintaining tissue homeostasis under steady-state conditions and the distinct contribution of bone marrow-derived macrophages (BMDMs) in promoting tissue regeneration and restoring respiratory system homeostasis in response to injuries. Elucidating the signalling pathways within inflammatory conditions, the impact of various triggers on tissue-resident alveolar macrophages (TR-AMs), as well as the recruitment and polarisation of macrophages originating from the bone marrow, presents an opportunity to propose innovative therapeutic approaches aimed at modulating the equilibrium between phenotypes to induce programmes associated with a pro-regenerative or homeostasis phenotype of BMDMs or TR-AMs. This, in turn, can lead to the amelioration of disease outcomes and the attenuation of detrimental inflammation. This review comprehensively addresses the pivotal role of macrophages in the orchestration of inflammation and resolution phases after lung injury, as well as ageing-related shifts and the influence of clonal haematopoiesis of indeterminate potential mutations on alveolar macrophages, exploring altered signalling pathways and transcriptional profiles, with implications for respiratory homeostasis.

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Section: The Aged Macrophagementioning

confidence: 99%

The guardians of pulmonary harmony: alveolar macrophages orchestrating the symphony of lung inflammation and tissue homeostasis

Pervizaj-Oruqaj,

Ferrero,

Matt

et al. 2024

Eur Respir Rev

View full text Add to dashboard Cite

show abstract

“…In this issue of the Journal , Yun and colleagues (pp. 1196–1205 ) apply a relatively novel approach to address this unmet need ( 4 ). Instead of performing whole-genome DNA sequencing, they conducted SNP calling analysis from bulk RNA sequencing data of lung samples from 1,251 subjects, including disease-free control subjects and patients with chronic lung diseases (mainly COPD and IPF), collected by the Lung Tissue Research Consortium.…”

mentioning

confidence: 99%

Somatic Mutations: The Next Frontier in Demystifying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis?

Yan,

Kaminski

2023

Am J Respir Crit Care Med

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Idiopathic Pulmonary Fibrosis: From Common Microscopy to Single-Cell Biology and Precision Medicine

Selman,

Pardo

2024

Am J Respir Crit Care Med

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Clonal Somatic Mutations in Chronic Lung Diseases Are Associated with Reduced Lung Function

Cited by 4 publications

References 27 publications

The guardians of pulmonary harmony: alveolar macrophages orchestrating the symphony of lung inflammation and tissue homeostasis

The guardians of pulmonary harmony: alveolar macrophages orchestrating the symphony of lung inflammation and tissue homeostasis

Somatic Mutations: The Next Frontier in Demystifying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis?

Idiopathic Pulmonary Fibrosis: From Common Microscopy to Single-Cell Biology and Precision Medicine

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