Clonal Relationships between Invasive and Carriage<i>Streptococcus pneumoniae</i>and Serotype‐ and Clone‐Specific Differences in Invasive Disease Potential

Brueggemann, Angela B.; Griffiths, David; Meats, Emma; Peto, Tim E. A.; Crook, Derrick W.; Spratt, Brian G.

doi:10.1086/374624

Cited by 551 publications

(512 citation statements)

References 30 publications

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“…Differences between serotypes in the risk of progression from carriage to acute otitis media were not as significant (12). Furthermore, carriage isolates tend to be genotypically more diverse than invasive isolates, whereas particular, clonal characteristics are likely to be advantageous for invasiveness (4,39).…”

Section: Discussionmentioning

confidence: 93%

“…Two strains expressing serotype 3 capsule survived equally well in the nasopharynx but in the lungs the mutant of serotype 2 strain became avirulent compared to either wild-type serotype 3 strain (20). In invasive pneumococcal disease the capsular serotype is assumed to be more important than the genotype, because individual serotypes vary in their invasive disease potential (4,13). Serogroups 1, 4, 5, 7, and 14 are strongly associated with invasive disease, whereas serotype 23F is associated with carriage (5).…”

Section: Discussionmentioning

confidence: 99%

“…The serotype 5 capsuleswitched mutants of the present study, prepared in the genetic backgrounds of TIGR4 and 603, were less resistant to complement in comparison with many other serotypes expressed in the same genetic background. The invasive disease potential of serotype 4 has been reported to be high compared to other serotypes (4,13). However, the exceedingly high estimation of the invasive disease potential of serotype 4 was based on a total of six cases, four of which had the same MLST, 205 (4).…”

Section: Discussionmentioning

confidence: 99%

“…The ability of nasopharyngeal carriage to progress into invasive disease or the risk of invasive disease after acquisition of the pathogen varies by serotype (4,13). The relative contribution of the capsular type compared to other virulence factors in pneumococcal diseases is still unclear, but the extent of virulence cannot be predicted from the capsular type only.…”

mentioning

confidence: 99%

“…The relative contribution of the capsular type compared to other virulence factors in pneumococcal diseases is still unclear, but the extent of virulence cannot be predicted from the capsular type only. Clones belonging to the same serotype can have different abilities to cause invasive disease (4,13,43).…”

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confidence: 99%

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The Capsular Serotype ofStreptococcus pneumoniaeIs More Important than the Genetic Background for Resistance to Complement

et al. 2010

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The polysaccharide capsule of Streptococcus pneumoniae inhibits phagocytic killing by innate immune mechanisms. Certain serotypes are associated with invasive disease while others with a nasopharyngeal carriage. The invasiveness of serotypes may partly be explained by ability to resist deposition of complement (C3) on the bacterial surface and consequent opsonophagocytic killing. In our previous studies, we observed that clinical isolates of serotypes 1 and 5, which are rarely detected in asymptomatic carriage, were resistant to complement deposition and opsonophagocytosis, whereas serotypes 6B and 23F, both common in carriage, were more sensitive to deposition of C3 and opsonophagocytic killing. However, presence of significant variation in C3 deposition between isolates of the same serotype indicated that factors other than the capsule also affect complement resistance. To distinguish the relative effect of the capsular serotype and other virulence factors on C3 deposition, we compared capsule-switched mutants prepared in genetic backgrounds of pneumococcal strains TIGR4, 603, and 618. Clinical isolates which had the same multilocus sequence type but expressed different serotypes were also compared. We found that the serotype had a significant impact on complement resistance and that the more resistant the strain was to complement, the higher was the concentration of polysaccharide-specific antibodies required for opsonophagocytic killing. Comparison of strains expressing the same capsular polysaccharides in the different genetic backgrounds and various capsular mutants of the same strain suggests that while the genotype affects complement resistance, the serotype is the most important determinant. Differences between serotypes were more significant than the differences between strains.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The Capsular Serotype ofStreptococcus pneumoniaeIs More Important than the Genetic Background for Resistance to Complement

et al. 2010

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Impact of pneumococcal vaccine response on asthma exacerbation frequency in young children

Eisenlohr

Chartrand

Barzaga

et al. 2020

Immunity Inflam & Disease

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Introduction Chronic asthma is a heterogeneous disease, and increased eosinophils have been shown to predict increased asthma exacerbations, especially in adults. Recent recommendations suggest the need for supplemental PPV‐23 vaccination in older children with chronic asthma. Methods To investigate differences in preschool asthma, our case‐cohort study comprised of 127 children, mean age 47 months (32‐65), with a history of asthma exacerbations requiring more than three courses of systemic steroid bursts and more than six antibiotics courses in the previous year. Results At baseline, mean antibody titer response to Streptococcus pneumoniae was decreased at 2.6 ± 2 out of 14 serotypes, despite prior complete pneumococcal conjugate vaccine (PCV) vaccinations. All children were readministered pneumococcal vaccinations with PCV‐13 booster and/or PPSV‐23. Mean postvaccination pneumococcal vaccine (PV) titer response was 16 ± 5 out of 23 serotypes. After contacting 91 parents/caretakers, 75 responded with less frequency of corticosteroids and antibiotic use for asthma exacerbations after PV. This group had baseline eosinophil counts of 211 ± 36/µL, while those without improvement were significantly higher at 371 ± 123/µL,*P < .05. There were no significant differences (P > .05) between the two groups from other baseline measures including demography or atopic status. Conclusions This subset of children with exacerbation‐prone asthma had poor antibody titer response to Streptococcus pneumoniae, even with prior complete PCV‐13 immunization. Identification of low antibody responses to PV serotypes may provide a targeted therapeutic approach to reduce wheezing exacerbations in a precise asthma phenotype in children.

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Pediatric parapneumonic pleural effusion: Epidemiology, clinical characteristics, and microbiological diagnosis

Hernández-Bou

García‐García

Esteva

et al. 2009

Pediatric Pulmonology

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Clonal Relationships between Invasive and CarriageStreptococcus pneumoniaeand Serotype‐ and Clone‐Specific Differences in Invasive Disease Potential

Cited by 551 publications

References 30 publications

The Capsular Serotype ofStreptococcus pneumoniaeIs More Important than the Genetic Background for Resistance to Complement

The Capsular Serotype ofStreptococcus pneumoniaeIs More Important than the Genetic Background for Resistance to Complement

Impact of pneumococcal vaccine response on asthma exacerbation frequency in young children

Pediatric parapneumonic pleural effusion: Epidemiology, clinical characteristics, and microbiological diagnosis

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