Clonal Proliferation of Type 2 Helper T Cells in a Man with the Hypereosinophilic Syndrome

Cogan, Elie; Schandené, Liliane; Crusiaux, Alain; Cochaux, Pascale; Velu, Thierry; Goldman, Michel

doi:10.1056/nejm199402243300804

Cited by 289 publications

(178 citation statements)

References 24 publications

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“…Magnetic resonance imaging showed the disappearence of bone lesions 12 months after subset could 'drive' some HES has been suggested. 7 Although our patient has not been examined for an underly-BMT. Bone marrow examination showed persistent hypocellularity without resolution of myelofibrosis.…”

mentioning

confidence: 90%

Allogeneic bone marrow transplantation for hypereosinophilic syndrome with advanced myelofibrosis

Sadoun

Lacotte

Delwail

et al. 1997

Bone Marrow Transplant

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Summary:Case reportA 33-year-old man with an atypical course of hypereoClinical history sinophilic syndrome including malignant hypercalce-The diagnosis of HES was made in December 1989, in a mia, osteolytic lesions and evolution into severe myelo-30-year-old man complaining of abdominal pain, diarrhea, fibrosis was treated by allogeneic bone marrow cough, diffuse myalgias and hypoesthesia of the left heel. transplantation after conditioning with cytoxan andHis body temperature fluctuated between 37°5C and 39°C. total body irradiation. As the transplant was sex-misPhysical examination revealed splenomegaly with the matched, chimerism was studied by means of cytospleen 6 cm below the costal margin. Echocardiogram genetic analysis and Y chromosomal DNA amplification detected no cardiac damage. Broncho-alveolar lavage by PCR assay. Long-term complete remission has been showed no eosinophilic pulmonary infiltrate. assessed by normalization of blood cell counts, magneticWhite blood cells (WBC) were 54 × 10 9 /l with 65% resonance imaging and karyotypic analysis. A relapse eosinophils, 20% neutrophils, 1% basophils, 13% lymphowas observed 40 months after transplantation. The cytes and 1% monocytes. The hemoglobin (Hb) was 13.7 patient remains alive 44 months post-BMT. This case g/dl and platelet count, 280 ϫ 10 9 /l. Leukocyte alkaline report is compared with those reported in the literature.phosphatase score was normal. Vitamin B12 and serum

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mentioning

confidence: 90%

Allogeneic bone marrow transplantation for hypereosinophilic syndrome with advanced myelofibrosis

Sadoun

Lacotte

Delwail

et al. 1997

Bone Marrow Transplant

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“…Aldolase, creatine phosphokinase, dence that cytokines produced by helper T cells stimulate the serum IgE level, and vitamin B12 and folic acid levels were proliferation of eosinophils. 4 It has been reported that interleuwithin normal limits. An echocardiogram and upper gastrokin (IL)-5, IL-3, and granulocyte-macrophage colony-stimulatintestinal series revealed no abnormalities.…”

Section: Patient 1 Idiopathic Hypereosinophilic Syndrome (Hes) Is a Smentioning

confidence: 98%

“…Control of eosinophil count is the first step in avoiding infections, and lymphomas that cause eosinophilia. Cogan et al 4 reported recently the clonal proliferation of type 2 helper or delaying clinical sequelae. We report here the first use of 2-CdA for idiopathic HES.…”

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confidence: 99%

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2-Chlorodeoxyadenosine therapy for idiopathic hypereosinophilic syndrome

et al. 1997

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“…Disorders with hyperlgE and/or hypereosinophilia, are reported to be associated with increased activity of type 2 helper T (Th2) lymphocytes, which secrete interleukin-4 (IL-4) and interleukin-5 (IL-5), com bined with a decreased activity of type 1 helper T cells, which produce interleukin-2 (IL-2) and interferon gam m a (IFN-y) [4,5). This Th2 pattern was recently described in a young girl with O m enn's © 1997 Blackwell Science Ltd syndrome [6 ].…”

Section: Introductionmentioning

confidence: 99%

An unusual case of severe combined immunodeficiency with hypereosinophilia

Dams

Mascart‐Lemone

Schandené

et al. 1997

Journal of Internal Medicine

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Abstract. Dams ETHM, Mascart-Lemone F, Schandené L, van der Meer JWM (University Hospital Nijmegen, Nijmegen, The Netherlands, and Hôpital Erasme, Brussels, Belgium). An unusual case of severe com bined immunodeficiency with hypereosinophilia (Case Report). J Intern Med 1997; 242: 2 6 7 -9 .Investigation of the cytokine profile in a 26-year-old m an, suffering from combined immunodeficiency with hypereosinophilia, revealed high levels of interleukin-4 and interleukin-5 and relatively low levels of interleukin-2 and interferon gam m a, consistent with a T-helper type 2 pattern, as has been reported in O m enn's syndrome. However, some distinct clinical and immunological features suggest that this case may represent a unique disease with specific patho genesis.

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Clonal Proliferation of Type 2 Helper T Cells in a Man with the Hypereosinophilic Syndrome

Cited by 289 publications

References 24 publications

Allogeneic bone marrow transplantation for hypereosinophilic syndrome with advanced myelofibrosis

Allogeneic bone marrow transplantation for hypereosinophilic syndrome with advanced myelofibrosis

2-Chlorodeoxyadenosine therapy for idiopathic hypereosinophilic syndrome

An unusual case of severe combined immunodeficiency with hypereosinophilia

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