Clonal identity between skin and synovial tissue in a case of mycosis fungoides with polyarthritis

Sandberg, Yorick; Abdouni, M'hamed El; Lam, King H.; Langerak, Anton W.; Lugtenburg, Pieternella J.; Dolhain, Radboud J E M; Heule, Freerk

doi:10.1016/j.jaad.2004.01.043

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…Other examples of clinicopathologic dissociation in dermatoncology are the prodromic, treacherous ecchymotic phase of angiosarcoma (which, when fullblown, is nodular-ulcerative); synovial mycosis fungoides presenting as rheumatoid arthritis [7]; and the so called "invisible dermatoses". This term is unfortunately ambiguous, being used in two different senses: clinically relevant skin lesions that lack evident, unless painstakingly searched, histologic correlates [8]; and skin diseases without clinically evident lesions but showing histologic changes of specific nature: this is especially the case of occult mycosis fungoides [9] and mastocytosis [10].…”

Section: The Problem: "Discrepancies" "Inconsis-tencies" "Mimickers" ...mentioning

confidence: 99%

Clinicopathologic Dissociation in Dermat[onc]ology – and Beyond

Capella

2022

J. Can. Res. Updates

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The concept of clinicopathologic dissociation is a neglected one in medicine. It refers to the unexpected, complete absence of concordance between the clinical picture and the underlying histopathologic finding. The recognition of such a phenomenon generally implies radically different treatment and follow-up choices. A rare phenomenon, it can however be encountered, especially in the field of dermatoncology and dermatology at large. It should be kept separate from clinicopathologic discordance or discrepancy, the term used by surgical pathologists to indicate the lack of expected molecular markers or to the presence of unexpected ones in the face of a given morphological diagnosis, albeit overlaps occur. More generally, the concept of clinicopathologic dissociation can be applied when a given clinical manifestation appears completely unrelated to the underlying objectively tracked primary disease. Examples are provided, and educational, ethical and medicolegal implications are briefly discussed.

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Section: The Problem: "Discrepancies" "Inconsis-tencies" "Mimickers" ...mentioning

confidence: 99%

Clinicopathologic Dissociation in Dermat[onc]ology – and Beyond

Capella

2022

J. Can. Res. Updates

View full text Add to dashboard Cite

show abstract

“…4 In patients with genetic susceptibility, malignant T cells can migrate through the joint and increase inflammation by producing cytokines such as interferon-γ and interleukin-2. 5 Regardless of the former explanations, rheumatoid arthritis and mycosis fungoides can coexist independently. Paraneoplastic joint involvement can also occur in mycosis fungoides and the severity of lymphoma correlates with joint involvement, as depicted in our case.…”

Section: Sirmentioning

confidence: 99%