“…Comparing the CH prevalence in our HIV cohort to other published cohorts of PWH is limited by variability in sequencing methodology and cohort characteristics (25)(26)(27)(28)(29). Studies in PWH using whole-exome data, with a lower sensitivity to detect CH at a VAF of 2% or greater, have found prevalences between 4% and 14% (26)(27)(28). Using a 24-gene panel, a study by van however, their cohort was notably older, with a median age of 63 years, and only 34.6% had a CD4 + nadir of less than 200 cells/μL, with 17% having a prior AIDS-defining condition (25).…”