Clonal Evolution of Radioresistance in Esophageal Squamous Cell Carcinoma by Single-Cell Whole Exome Sequencing

Abstract

Conclusion: Tumor voxel dose response SF2 can be derived using multiple FDG-PET imaging obtained during the early weeks of radiation treatment. Distribution of SF2 has significant predictability power on tumor local failure, and the recurrent location. It can be used as the objective function to target radio-resistant tumor cells.