Clonal competition assays identify fitness signatures in cancer progression and resistance in multiple myeloma
Larissa Haertle,
Umair Munawar,
Hipólito N. C. Hernández
et al.
Abstract:Multiple myeloma (MM) is a genetically heterogeneous disease and the management of relapses is one of the biggest clinical challenges. TP53 alterations are established high‐risk markers and are included in the current disease staging criteria. KRAS is the most frequently mutated gene affecting around 20% of MM patients. Applying Clonal Competition Assays (CCA) by co‐culturing color‐labeled genetically modified cell models, we recently showed that mono‐ and biallelic alterations in TP53 transmit a fitness advan… Show more
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