DOI: 10.11606/t.17.2016.tde-05012016-091813
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Clonagem e expressão do fator VII de coagulação sanguínea em linhagens celulares humanas

Abstract: Recombinant factor VII (FVIIr) has been the main therapeutic choice for hemophilic patients who develop inhibitors antibidies to conventional treatments (FVIII and FIX). Currently, the comercial product is produced in murine cells (BHK-21) which gives disadvantages considering the complexity of post-translational modifications of these proteins. The insertion of murine residues can be highly immunogenic in humans. Thus the production of proteins for therapeutic use in human cell lines appears as a promising a… Show more

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