Clomipramine versus placebo in the treatment of premature ejaculation: A pilot study

Rt, Segraves; Saran, Anand; Segraves, K. B.; Maguire, E.D.

doi:10.1080/00926239308404904

Cited by 109 publications

(57 citation statements)

References 2 publications

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“…Between 1973 and 2003, there have been 35 studies 15,17,23-25,60-79,80,81 on daily treatment with clomipramine, a tricyclic antidepressant, and on SSRIs (Table 2). In the same period, on-demand antidepressant treatment results were reported in eight studies [82][83][84][85][86][87][88][89] (Table 3). The current review consists of 3034 males obtained from 79 studies.…”

Section: General Results Of Reviewmentioning

confidence: 99%

“…Moreover, apart from one double-blind study with a watch, 87 there are as yet no double-blind studies using a stopwatch for on-demand treatment. Similarly, all double-blind Meta-analysis of early ejaculation drug treatment MD Waldinger et al on-demand placebo treatments [82][83][84] were evaluated without a stopwatch.…”

Section: Meta-analysis Of On-demand Treatmentsmentioning

confidence: 99%

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Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis

et al. 2004

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The aim of this systematic review and meta-analysis is to evaluate whether the design and methodology of drug-treatment studies of premature ejaculation affect the efficacy outcome differently. Therefore, methodological, design and efficacy data from 79 studies (3034 males), published between 1943 and 2003, are reviewed. A meta-analysis is performed on 43 selective serotonin reuptake inhibitors (SSRIs) and clomipramine studies (1514 males), published between 1973 and 2003; these studies were pooled to provide a summary variance-weighted effect size. The antidepressant-induced percentage increase of the intravaginal ejaculation latency time (IELT) was calculated and examined against various methodological items. A significant difference in efficacy between SSRIs was observed. Using daily treatment, paroxetine appeared more effective than the other SSRIs. Retrospective use of a questionnaire, subjective reports, single-blind and open study designs generate far greater variability of ejaculation time both at baseline and during active drug treatment than real time assessment by stopwatch. In conclusion, at daily treatment, the overall efficacy of paroxetine, clomipramine, sertraline and fluoxetine is comparable, but paroxetine exerts the strongest ejaculation delay. Only eight (18.5%) studies on antidepressant treatment fulfilled all criteria used in evidence-based medicine, for example, randomised, double-blind studies with prospective real time (stopwatch) assessment of the IELT at each intercourse. Single-blind studies, open designs, retrospective reporting, or the use of a questionnaire to assess ejaculation time should be avoided.

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Section: General Results Of Reviewmentioning

confidence: 99%

Section: Meta-analysis Of On-demand Treatmentsmentioning

confidence: 99%

Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis

et al. 2004

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“…because of the unclarified mechanism and systemic side effects. [5][6][7][8] Attempting to elucidate the etiologic bases of PE, we had investigated penile sensory threshold changes in patients with primary PE, and found that patients with PE…”

Section: The Bcrap Changesmentioning

confidence: 99%

“…[5][6][7][8] Recently, neurobiological studies have made it likely that PE is not only a psychological disorder but a neurobiological phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Effects of Renewal SS-cream on the Bulbocavernosus Reflex (BCR) in Rabbits

Tian

Jin

et al. 2008

Chonnam Med J

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Renewal SS-cream is a topical agent modified from the original SS-cream which is effective in the treatment of premature ejaculation. In this study, the efficacy of renewal SS-cream on premature ejaculation caused by the bulbocavernosus reflex (BCR) was investigated in rabbits. Sixty male New Zealand white rabbits (weights: 2.5∼3.0 kg) were divided into 3 groups randomly. Either renewal or original SS-cream or placebo (provided by CJ Co. LTD) was topically applied to the glans penis of rabbits in a double-blind manner. The bulbocavernosus reflex (BCR) was elicited by electrical stimulation of the glans penis. The latency of BCR (BCRLT) and the amplitude of BCR (BCRAP) were recorded on an electrophysiograph (Poseidomn, Shanghai, China) before and at 10, 30 and 60 min after application of the test agents. Representative tracings of BCRLT and BCRAP were recorded and analyzed. The mean BCRLT values were significantly prolonged in post-application groups of SS-cream Ⓡ and renewal SS-cream Ⓡ , compared with those in pre-application and placebo groups (p＜0.05). There was no significant difference in efficacy between SS-cream Ⓡ and renewal SS-cream Ⓡ groups (p＞0.05). The mean BCRAP showed decreasing tendency following application of SS-cream Ⓡ and renewal SS-cream Ⓡ ; however, they were not significantly different (p＞0.05). Both of original SS-cream Ⓡ and renewal SS-cream Ⓡ prolonged the BCRLT after their application to the glans penis in rabbits. The results indicate that they have local desensitizing effects on the sensory receptors of the dorsal nerve of the glans penis and may help control the ejaculatory reflex in patients with premature ejaculation.

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“…This, combined with the development of a variety of effective therapeutic agents, has opened the door for allowing substantial improvement in this domain of medical practice. [25][26][27][28] Clearly, both as a proactive issue of wellness and as an area of investigation in the management of illness, the quality and satisfaction of a patient's sexual functioning should be a major area of focus for a physician. Physicians, however, have indicated a number of factors that serve as barriers to addressing sexual health with their patients including: physician's self-perceived inadequate knowledge and training, time constraints, patient embarrassment, as well as physicians own feelings of discomfort with the topic.…”

Section: Introductionmentioning

confidence: 99%

Medical students' perceptions of sexual health issues prior to a curriculum enhancement

et al. 2003

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The objectives were to compare first, second and third year medical students on self-perceived sexual health knowledge, comfort in addressing sexual health problems, and attitudes towards the importance of addressing sexual health issues with patients as part of a sexual health medical curriculum enhancement project. A paper-and-pencil questionnaire survey was designed and administered to first and second year medical students at the start of the fall semester, resulting in high participation rates for both years (98% and 86%, respectively). Third year students were surveyed through an on-line version of the questionnaire yielding a lower response rate (52%). Multivariate statistical analyses were used to compare knowledge, comfort and attitudes by year in medical school. Results were as follows: As might be expected, sexual health knowledge and comfort in addressing sexual health problems increased linearly from first to third year (Po0.01) for all questions. Unexpectedly, second year students had significantly higher scores on questions assessing attitudes towards the importance of addressing sexual health issues than either first or third year students (Po0.001). Female medical students reported that addressing sexual health issues with patients was significantly more important than did male medical students; however, male students reported higher levels of self-reported knowledge and comforting related to sexual health issues than did female students in a number of areas. In conclusion, knowledge gained from this survey was used to finalize the design of an enhanced, integrated curriculum on sexual health for medical students. Further investigation of gender differences related to training medical students in this area is suggested. International Journal of Impotence Research (2003) 15, Suppl 5, S58-S66. doi:10.1038/ sj.ijir.3901074Keywords: sexual health; medical school curriculum; sex education; sexual attitudes; medical students IntroductionThe World Health Organization 1 , in concert with the General Assembly of the World Association of Sexology (WAS), put forth a report outlining 11 sexual rights. These include the right to sexual pleasure; the right to sexual freedom; the right to sexual autonomy, sexual integrity and the safety of the sexual body; the right to sexual information based on scientific inquiry; the right to comprehensive sexuality education; the right to sexual health care and the right to sexually associate freely, etc. 2 The translation of such policy statements into reality will, for many individuals, require the proactive support of health professionals. 3 Conversely, sexual dysfunction is a prevalent public health problem. Sexual dysfunction can be a primary presentation, a symptom associated with a disease process, related to psychosocial concerns, or a side effect of medication. A large nationally representative study using the National Health and Social Life Survey (NHSLS) data reports that 43% of US women and 31% of US men indicate the presence of a sexual complaint. These repor...

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Clomipramine versus placebo in the treatment of premature ejaculation: A pilot study

Cited by 109 publications

References 2 publications

Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis

Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis

Effects of Renewal SS-cream on the Bulbocavernosus Reflex (BCR) in Rabbits

Medical students' perceptions of sexual health issues prior to a curriculum enhancement

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