Clomipramine Treatment of Stereotypic Behaviors and Self-Injury in Patients with Developmental Disabilities

Garber, Howard; McGonigle, John J.; Slomka, Gregory T.; Monteverde, E

doi:10.1097/00004583-199211000-00027

Cited by 64 publications

(13 citation statements)

References 10 publications

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“…The tricyclic antidepressant and non-selective but potent SRI clomipramine produced a marked decrease in stereotypic behaviors and self-injury in 10 of 11 subjects with ID in an open-label trial (Garber et al 1992). A subsequent double-blind, placebo-controlled crossover study yielded similar results, with a clinically significant reduction in the frequency of SIB in 6 of 8 adults with ID.…”

Section: Srismentioning

confidence: 76%

Multidisciplinary Assessment and Treatment of Self-Injurious Behavior in Autism Spectrum Disorder and Intellectual Disability: Integration of Psychological and Biological Theory and Approach

Minshawi

Hurwitz

Morriss

et al. 2014

J Autism Dev Disord

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The objective of this review is to consider the psychological (largely behavioral) and biological [neurochemical, medical (including genetic), and pharmacological] theories and approaches that contribute to current thinking about the etiology and treatment of self-injurious behavior (SIB) in individuals with autism spectrum disorder and/or intellectual disability. Algorithms for the assessment and treatment of SIB in this context, respectively, from a multidisciplinary, integrative perspective are proposed and challenges and opportunities that exist in clinical and research settings are discussed.

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Section: Srismentioning

confidence: 76%

Multidisciplinary Assessment and Treatment of Self-Injurious Behavior in Autism Spectrum Disorder and Intellectual Disability: Integration of Psychological and Biological Theory and Approach

Minshawi

Hurwitz

Morriss

et al. 2014

J Autism Dev Disord

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“…In treatmentresistant cases, other serotonergic anti depressant agents such as clomipramine may be effective (Garber 1992).…”

Section: Antidepressants and Anxiolyticsmentioning

confidence: 99%

Psychopharmacology in children with intellectual disability

Bramble¹

2011

Adv. psychiatr. treat

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David Bramble is one of a growing number of child psychiatrists who specialise entirely in the mental health of children with intellectual disability and presently works in a multidisciplinary team in Shropshire. He has had a long-standing interest in autism, psychopharmacology and prescribing practices, particularly in respect of the management of attention-deficit hyperactivity disorder and common sleep disorders, and has lectured and published widely on these and related areas.

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“…These authors observed that clomipramine treatment was associated with improvement in the intensity of SIB, the frequency of stereotypy and compulsions, and a decrease in staff-reported interventions for problem behaviours. Garber et al (1992) demonstrated that clomipramine was effective in decreasing chronic stereotypic and SIB such as head banging, head and face slapping, arm biting, eye gouging, aggression and tantrums in 10 out of 11 adolescents with developmental disorders. In a prospective open trial of clomipramine, Brodkin et al (1997) observed that 55 % of the 33 adults with Pervasive Developmental Disorder who completed the 12-wk trial were treatment responders, with clomipramine reducing repetitive thoughts and behaviours, aggression and improving social responsiveness.…”

Section: Introductionmentioning

confidence: 99%

Serotonergic antidepressant effects on aggressive, self-injurious and destructive/disruptive behaviours in intellectually disabled adults: a retrospective, open-label, naturalistic trial

Janowsky

Shetty

Barnhill

et al. 2005

Int. J. Neuropsychopharm.

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There is a growing body of evidence that serotonergic antidepressants are useful in the treatment of maladaptive behaviours in the intellectually disabled. However, not all studies have shown positive results due to lack of efficacy, tolerance development, and troublesome side-effects. The current study consisted of a review of the treatment response to a variety of serotonergic antidepressants, consisting of selective serotonin reuptake inhibitors (SSRIs ) (n = 36) and clomipramine (n = 2) in 38 institutionalized intellectually disabled adults (20 males, 18 females; mean age 45.6 yr, age range 18-74 yr). Those studied were treated for aggression, self-injurious behaviours, destructive/disruptive behaviours, depression/dysphoria, or a combination of these or other challenging behaviours. Most were receiving concurrent psychotropic and/or anticonvulsant medications. Effectiveness was determined by a retrospective review of the summaries of multidisciplinary Neuropsychiatric Behavioural Reviews (NBRs) in which global and specific maladaptive behaviours were rated on a 1- to 7-point scale, and by psychologists' ratings of target behaviours. Overall, statistically significant decreases in the ratings of global maladaptive behaviour and aggression, self-injurious behaviour, destruction/disruption and depression/dysphoria and in psychologists' ratings occurred in the subject group after the initiation of antidepressants. The results suggest that serotonergic antidepressants are useful in the treatment of challenging/maladaptive behaviours in the intellectually disabled.

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Clomipramine Treatment of Stereotypic Behaviors and Self-Injury in Patients with Developmental Disabilities

Cited by 64 publications

References 10 publications

Multidisciplinary Assessment and Treatment of Self-Injurious Behavior in Autism Spectrum Disorder and Intellectual Disability: Integration of Psychological and Biological Theory and Approach

Multidisciplinary Assessment and Treatment of Self-Injurious Behavior in Autism Spectrum Disorder and Intellectual Disability: Integration of Psychological and Biological Theory and Approach

Psychopharmacology in children with intellectual disability

Serotonergic antidepressant effects on aggressive, self-injurious and destructive/disruptive behaviours in intellectually disabled adults: a retrospective, open-label, naturalistic trial

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