Clomiphene citrate does not affect the secretion of alpha3, alphaV and beta1 integrin molecules during the implantation window in patients with unexplained infertility

Abstract

Our study indicated that cc treatment significantly decreased the endometrial thickness and increased oestradiol and progesterone concentrations. However, secretion of alpha(v), beta1 and alpha3 integrin molecules, which might play a role in implantation, was not affected.

Focal Adhesion Proteins, Vinculin and Integrin β5, During Early Pregnancy in Rat Uterine Epithelial Cells: Anastrozole Favors their Normal Distribution

“…This agrees with earlier studies that also observed a decrease in uterine integrin β3 expression in chlomiphene citrate (CC) treated patients during the window of implantation, suggesting that chlomiphene citrate (CC) might affect the expression of uterine receptivity markers (Palomino et al, 2005). On the contrary, other studies noted that chlomiphene citrate (CC) does not affect the secretion of integrin α3, integrin aV and integrin b1 during the implantation window in patients with unexplained infertility (Lacin et al, 2001). All in all, chlomiphene citrate (CC) appears to negatively affect the implantation process by down-regulating the expression of key implantation markers such as vinculin and integrin β5 and thus being associated with low pregnancy rates.…”

Effects of letrozole and clomiphene citrate on the expression of HOXA10 and integrin αvβ3 in uterine epithelium of rats

“…Some investigators have shown that clomiphene does not affect the expression of integrins in the endometrium of women compared with control cycles (15,16), but others have reported that CC treatment could impair uterine receptivity by down-regulating epithelial integrins (17,18). One possible explanation is that the dosage regimen, isoforms of integrins, and method of detection in these studies may be different.…”

Endometrial receptivity markers in infertile women stimulated with letrozole compared with clomiphene citrate and natural cycles

“…Creus et al [2003] have reported that pinopod formation, but not a v b 3 integrin expression, is significantly reduced in CC-treated cycles as compared to controls. Another group has shown that CC treatment does not affect a v b 3 integrin secretion in women with unexplained infertility as compared to spontaneous cycles [Lacin et al 2001]. Interestingly, Palomino and co-workers [2005] have reported that CC administration reduces endometrial b 3 integrin expression only in out-of phase endometria of normoovulatory women as compared to spontaneous cycles.…”

“…The level of integrin expression in CC treated cycles has been studied earlier in out-of phase endometrium [Gonzalez et al 2001;Palomino et al 2005] and in the in-phase endometria [Lacin et al 2001]. …”