Cloke–Wilson rearrangement: a unique gateway to access five-membered heterocycles

Abstract

Cloke–Wilson rearrangement is utilized to process cyclopropyl constituting functional groups and results in stable five-membered heterocycles. This rearrangement is also involved in the total synthesis of various natural products.

Baeyer–Villiger oxidation: a promising tool for the synthesis of natural products: a review

“…Five-membered heterocyclic compounds are fundamental in medicinal chemistry due to their antifungal, antibacterial, and antiviral properties. 52 Homoproaporphine alkaloids ( i.e. , (+)-regeline, (+)-jolantidine, and (+)-regilinine, etc. )…”

“…(−)-Misramine 26 is a pentacyclic proaporphine alkaloid, 52 a member of isoquinoline alkaloids. 60 The former is a biologically active compound and was found in Roemeria hybrida and R. dodecandra .…”