Clodronate prevents immobilization osteopenia in rats

Tarvainen, Riitta; Arnala, I; Olkkonen, H.; Lappalainen, R; Nevalainen, Timo J.; Alhava, E

doi:10.3109/17453679408994622

Cited by 14 publications

(5 citation statements)

References 13 publications

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“…Generally, bone mineral contents are significantly decreased in osteoporotic status. Among bone mineral contents, Ca and P contents are the most dramatically decreased in osteoporotic bone, but their ratio, Ca/P, generally does not change (Tanaka et al, 2001;Tarvainen et al, 1994). LBP significantly increased the tibiae Ca and P contents that were decreased by ovariectomy.…”

Section: Effect Of Lbp On Rats' Body Weight Bmd and Bmcmentioning

confidence: 94%

Extraction, characterization of polysaccharides from lycium barbarum and its effect on bone gene expression in rats

Zhu¹,

Jinggang²,

Changsheng³

et al. 2010

Carbohydrate Polymers

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Section: Effect Of Lbp On Rats' Body Weight Bmd and Bmcmentioning

confidence: 94%

Extraction, characterization of polysaccharides from lycium barbarum and its effect on bone gene expression in rats

Zhu¹,

Jinggang²,

Changsheng³

et al. 2010

Carbohydrate Polymers

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“…( 3 ) Bisphosphonates, parathyroid hormone, and ipriflavone have been reported to prevent bone loss caused by NX in rats. ( 4–9 )…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin K2 on Cortical and Cancellous Bones in Orchidectomized and/or Sciatic Neurectomized Rats

Iwamoto¹,

Yeh²,

Takeda³

2003

Journal of Bone and Mineral Research

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We examined the effect of vitamin K 2 on cortical and cancellous bones in orchidectomized and/or sciatic neurectomized rats. Ninety male Sprague-Dawley rats, 3 months of age, were randomized by stratified weight method into nine groups with 10 rats in each group: baseline control (BLC), age-matched intact control (IN), IN؉vitamin K 2 administration (K), orchidectomy (ORX), ORX؉K, unilateral sciatic neurectomy (NX), NX؉K, ORX؉NX (ONX), and ONX؉K. Vitamin K 2 (menatetrenone) was administered orally twice a week at a dose of 30 mg/kg each. After 10 weeks of feeding, the tibial shaft and proximal tibia were processed for cortical and cancellous bone histomorphometric analyses, respectively. An ORX-induced reduction in maturation-related cortical bone gain and ORX-induced cancellous bone loss were attributable to increased endocortical and trabecular bone turnover, respectively. NX-and ONX-induced reductions in maturationrelated cortical bone gain were attributable to decreased periosteal bone formation and increased endocortical bone turnover, while NX-and ONX-induced cancellous bone loss was attributable to increased bone resorption and decreased bone formation. ORX-induced cancellous bone loss was more pronounced when combined with immobilization. Vitamin K 2 administration did not significantly alter any parameters in IN rats. Vitamin K 2 administration in ORX rats suppressed endocortical bone resorption and trabecular bone turnover, retarding a reduction in maturation-related cortical bone gain and cancellous bone loss. This effect on cancellous bone loss was primarily because of prevention of a reduction of trabecular thickness. Vitamin K 2 administration in NX and ONX rats suppressed bone resorption and stimulated bone formation (mineralization), with retardation of a reduction of trabecular thickness without any significant effect on cancellous bone mass, and suppressed endocortical bone resorption, retarding a reduction in maturation-related cortical bone gain. The present study provides evidence indicating that vitamin K 2 has the potential to suppress bone resorption or bone turnover and/or stimulate bone formation in vivo in ORX and/or NX rats. (J Bone Miner Res 2003;18:776 -783)

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“…Of the bone mineral contents, Ca and P are the most dramatically decreased in the bone but their ratio, Ca/P, was not generally changed (Tarvainen et al, 1994;Tanaka et al, 2001). The MR extracts significantly increased the tibia contents of Ca and P decreased by neurectomy.…”

Section: Discussionmentioning

confidence: 94%

Effect of Mornidae Radix extracts on experimental osteoporosis in sciatic neurectomized mice

Seo

Myoung

et al. 2005

Phytother. Res.

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The preventive and therapeutic effects of aqueous extracts of Mornidae Radix (MR) were observed in sciatic neurectomized mice, a disused osteoporotic model. The right hind limbs of 80 mice were neurectomized and 20 mice were sham-operated and served as a sham control. Then 50, 100 and 200 mg/kg of MR extracts were dosed 3 days after neurectomy for 6 weeks in the prevention study and were dosed 2 weeks after neurectomy for 12 weeks for the therapeutic study. After dosing with the MR extracts, the thickness of the hind limbs, tibia failure load, tibia bone mineral density (BMD), serum osteocalcin levels, tibia calcium (Ca) and phosphorus (P) contents were monitored with histomorphometrical changes of the tibia. In both the prevention and therapeutic studies, the MR extracts significantly and dose-dependently suppressed the decrease in hind limb thickness, tibia failure load, BMD, tibia Ca and P contents with an increase in serum osteoclacin levels. In addition, the MR extracts also significantly and dose-dependently suppressed the decrease in histomorphometrical parameters of the tibia such as volume, length and thickness of trabecular bone and thickness of cortical bone with an increase in osteoclast cells in both the prevention and therapeutic studies. Based on these results, the MR extracts may act as both a suppressor of bone resorption and an enhancer of bone formation in vivo and may have some favorable effects for preventing and treating the osteoporosis induced by sciatic neurectomy.

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Clodronate prevents immobilization osteopenia in rats

Cited by 14 publications

References 13 publications

Extraction, characterization of polysaccharides from lycium barbarum and its effect on bone gene expression in rats

Extraction, characterization of polysaccharides from lycium barbarum and its effect on bone gene expression in rats

Effect of Vitamin K2 on Cortical and Cancellous Bones in Orchidectomized and/or Sciatic Neurectomized Rats

Effect of Mornidae Radix extracts on experimental osteoporosis in sciatic neurectomized mice

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