Clobetasol propionate shampoo 0.05% and calcipotriol solution 0.005%: A randomized comparison of efficacy and safety in subjects with scalp psoriasis

Abstract

Short contact therapy of scalp psoriasis with this new shampoo formulation of clobetasol propionate was significantly more effective and better tolerated than calcipotriol solution for the treatment of scalp psoriasis.

Treatment of severe scalp psoriasis: From the Medical Board of the National Psoriasis Foundation

“…40 Corticosteroids are more effective than other topical therapies, such as calcipotriene, coal tar, and probably tazarotene, based on a limited number of head-tohead studies comparing them. [5][6][7][8][9] No studies are available to support the safety of topical corticosteroid use on the scalp beyond 4 weeks. 40 Epidemiologic studies have shown, though, that many patients use corticosteroids for more than 8 weeks.…”

Scalp psoriasis: European consensus on grading and treatment algorithm

“…32 In a randomized, parallel-group comparison of clobetasol propionate shampoo 0.05% and calcipotriol solution 0.05%, adverse events were more common in the calcipotriol group than in the clobetasol propionate shampoo group. 24 A single-centre, randomized study in 26 patients with scalp psoriasis confirmed that unlike clobetasol propionate gel, clobetasol propionate shampoo 0.05% does not lead to HPA axis suppression, is not atrophogenic, and does not have any effect on ocular safety. 34 The use of clobetasol propionate foam 0.05% is also associated with few adverse events, limited to mild and transient burning, or other application-site reactions.…”

“…A vehicle-controlled, 4-week study in 142 patients with scalp psoriasis confirmed that the treatment was significantly more effective at reducing patients' total severity score (TSS) than vehicle alone (P < 0.001). 21 Active comparator trials have also found that clobetasol propionate shampoo is significantly more effective than calcipotriol solution (P ¼ 0.016), 24 and tar-blend shampoo 1%…”

“…17,19 Moreover, in the comparison of calcipotriol solution with clobetasol propionate shampoo noted above, the corticosteroid was again superior. 24 Combinations of some treatments have also been studied. A two-compound scalp formulation containing calcipotriol 50 lg/g and betamethasone dipropionate 0.5 mg/g has recently been examined in two randomized, controlled trials.…”

Topical Corticosteroids in Dermatology: From Chemical Development to Galenic Innovation and Therapeutic Trends

“…By contrast, the new MF cream and emulsion have an external aqueous phase and are real O/W formulations that make them also suitable for the treatment of acute inflammatory conditions. Together with the new MF formulations, Clobetasol Propionate (CP) shampoo has been developed for short-term contact therapy of inflammatory scalp conditions [36]. CP and betamethasone valerate are also available as foams [37].…”