Clobazam en Epilepsias Refractarias del Niño

Abstract

Clobazam in Children with Refractory EpilepsyTwenty three patients with refractory epilepsy (14 males and 9 females) and high seizure frecuency, all younger than 18 years old, were treated with Clobazam (Frizin®) added to conventional anticonvulsants. Doses of 0,5 -2 mg/kg/day, not exceeding 40 rng/day, were used. Complete seizure relief was achieved in 46% of the cases (11 patients) for an average follow up period of 5 months and 27 days. An important reduction in the frecuency of seizures was seen in 21% of the patients (5 cases). Recurrence of seizures after 2 to 3 months of good response to treatment ocurred in 5 patients (21 %). The best results were observed in secondary generalized epilepsies.El tratamiento de la epilepsia refractaria aun represents un desafio clinico a pesar de la introduction de nuevas drogas anticonvulsivantes. Partimos de la base que la monoterapia, con control de niveles plasmaticos es el tratamiento de election, sin embargo en algunos pacientes no se logra buena respuesta con una o mas drogas anticonvulsivantes, muchas de las cuales tienen efectos colaterales potencialmente serios.