Md. Golam Mostofa, Muhammad Arifur Rahman, Naoki Koike, Akter MST Yeasmin, Nafisa Islam, Talukdar Muhammad Waliullah, Shun Hosoyamada, Mitsugu Shimobayashi, Takehiko Kobayashi, Michael N. Hall, Takashi Ushimaru
Abstract:Nutrient starvation or inactivation of target of rapamycin complex 1 (TORC1) in budding yeast induces nucleophagy, a selective autophagy process that preferentially degrades nucleolar components. DNA, including ribosomal DNA (rDNA), is not degraded by nucleophagy, even though rDNA is embedded in the nucleolus. Here, we show that TORC1 inactivation promotes relocalization of nucleolar proteins and rDNA to different sites. Nucleolar proteins move to sites proximal to the nuclear-vacuolar junction (NVJ), where mi…
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