Clinimetrics and feasibility of the Italian version of the Frontal Assessment Battery (FAB) in non-demented Parkinson’s disease patients

Aiello, Edoardo Nicolò; D’Iorio, Alfonsina; Solca, Federica; Torre, Silvia; Bonetti, Ruggero; Scheveger, Francesco; Colombo, Eleonora; Maranzano, Alessio; Maderna, Luca; Morelli, Claudia; Doretti, Alberto; Amboni, Marianna; Verde, Federico; Ferrucci, Roberta; Barbieri, S.; Zirone, Eleonora; Priori, Alberto; Pravettoni, Gabriella; Santangelo, Gabriella; Silani, Vincenzo; Ticozzi, Nicola; Ciammola, Andrea; Poletti, Barbara

doi:10.1007/s00702-023-02624-7

Cited by 1 publication

(2 citation statements)

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“…In the context of construct validity and diagnostic analyses, the MoCA was considered as an outcome, both in accordance with the MDS recommendations to use this test for screening purposes in this population [ 50 ] and given that the MoCA is widely known to highly load on executive-based cognitive processes [ 48 ], as is the case with VF tests [ 51 ]. In support to such an approach, the MoCA has already been used earlier as an outcome measure for testing the validity and diagnostics of executive-loaded tests in both normotypical [ 48 , 52 ] and extrapyramidal populations [ 31 , 35 ].…”

Section: Methodsmentioning

confidence: 99%

“…, normality thresholds—might be poorly sensitive and, at variance, disproportionately biased towards specificity [ 28 , 29 ]. Due to the detrimental entailments of such a stance towards clinical and research practice, researchers in the field of cognitive testing often commit to provide users with disease-specific cut-offs [ 28 – 37 ]—at least with regard to those brain disorders that are among the most prevalent and incident, as is the case for PD [ 35 – 39 ].…”

Section: Introductionmentioning

confidence: 99%

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Psychometrics and diagnostics of the Italian version of the Alternate Verbal Fluency Battery (AVFB) in non-demented Parkinson’s disease patients

Aiello,

Mameli,

Ruggiero

et al. 2024

Neurol Sci

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Background Verbal fluency (VF) tasks are known as suitable for detecting cognitive impairment (CI) in Parkinson’s disease (PD). This study thus aimed to evaluate the psychometrics and diagnostics of the Alternate Verbal Fluency Battery (AVFB) by Costa et al. (2014) in an Italian cohort of non-demented PD patients, as well as to derive disease-specific cut-offs for it. Methods N = 192 non-demented PD patients were screened with the Montreal Cognitive Assessment (MoCA) and underwent the AVFB—which includes phonemic, semantic and alternate VF tests (PVF; SVF; AVF), as well as a Composite Shifting Index (CSI) reflecting the “cost” of shifting from a single- to a double-cued VF task. Construct validity and diagnostics were assessed for each AVFB measure against the MoCA. Internal reliability and factorial validity were also tested. Results The MoCA proved to be strongly associated with PVF, SVF and AVF scores, whilst moderately with the CSI. The AVFB was internally consistent and underpinned by a single component; however, an improvement in both internal reliability and fit to its factorial structure was observed when dropping the CSI. Demographically adjusted scores on PVF, SVF and AVF tests were diagnostically sound in detecting MoCA-defined cognitive impairment, whilst this was not true for the CSI. Disease-specific cut-offs for PVF, SVF and AVF tests were derived. Discussion In conclusion, PVF, SVF and AVF tests are reliable, valid and diagnostically sound instruments to detect cognitive impairment in non-demented PD patients and are therefore recommended for use in clinical practice and research.

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